Literature DB >> 2641456

Cerebral blood flow, oxygen and glucose metabolism with PET in progressive supranuclear palsy.

M Otsuka1, Y Ichiya, Y Kuwabara, Y Miyake, T Tahara, K Masuda, S Hosokawa, I Goto, M Kato, A Ichimiya.   

Abstract

Cerebral blood flow, cerebral oxygen metabolic rate and cerebral glucose metabolic rate were measured with positron emission tomography (PET) in four patients with progressive supranuclear palsy (PSP). Decreased blood flow and hypometabolism of oxygen and glucose were found in both subcortical and cortical regions, particularly in the striatum including the head of the caudate nucleus and the frontal cortex. The coupling between blood flow and metabolism was preserved even in the regions which showed decreased blood flow and hypometabolism. These findings indicated the hypofunction, as revealed by decreased blood flow and hypometabolism on PET, both in the striatum and the frontal cortex, and which may underlie the pathophysiological mechanism of motor and mental disturbance in PSP.

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Year:  1989        PMID： 2641456     DOI： 10.1007/bf03178296

Source DB:  PubMed          Journal:  Ann Nucl Med        ISSN： 0914-7187            Impact factor:   2.668


  25 in total

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Authors:  H Ishino; S Otsuki
Journal:  J Neurol Sci       Date:  1976-07       Impact factor: 3.181

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Journal:  Neurology       Date:  1967-06       Impact factor: 9.910

4.  Positron emission tomography and histopathology in Pick's disease.

Authors:  H Kamo; P L McGeer; R Harrop; E G McGeer; D B Calne; W R Martin; B D Pate
Journal:  Neurology       Date:  1987-03       Impact factor: 9.910

5.  Alternative approach to single-scan estimation of cerebral glucose metabolic rate using glucose analogs, with particular application to ischemia.

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Journal:  J Cereb Blood Flow Metab       Date:  1984-03       Impact factor: 6.200

6.  Correction for the presence of intravascular oxygen-15 in the steady-state technique for measuring regional oxygen extraction ratio in the brain: 2. Results in normal subjects and brain tumour and stroke patients.

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Journal:  J Cereb Blood Flow Metab       Date:  1983-12       Impact factor: 6.200

7.  Computed tomography and positron emission transaxial tomography evaluations of normal aging and Alzheimer's disease.

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Journal:  J Cereb Blood Flow Metab       Date:  1983-09       Impact factor: 6.200

8.  Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography.

Authors:  R S Frackowiak; C Pozzilli; N J Legg; G H Du Boulay; J Marshall; G L Lenzi; T Jones
Journal:  Brain       Date:  1981-12       Impact factor: 13.501

9.  Subcortical dementia. Frontal cortex hypometabolism detected by positron tomography in patients with progressive supranuclear palsy.

Authors:  R D'Antona; J C Baron; Y Samson; M Serdaru; F Viader; Y Agid; J Cambier
Journal:  Brain       Date:  1985-09       Impact factor: 13.501

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Authors:  J C Steele
Journal:  Brain       Date:  1972       Impact factor: 13.501
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  4 in total

1.  Positron emission tomography in asymptomatic gene carriers of Machado-Joseph disease.

Authors:  B W Soong; R S Liu
Journal:  J Neurol Neurosurg Psychiatry       Date:  1998-04       Impact factor: 10.154

2.  Regional patterns of cerebral glucose metabolism in spinocerebellar ataxia type 2, 3 and 6 : a voxel-based FDG-positron emission tomography analysis.

Authors:  Po-Shan Wang; Ren-Shyan Liu; Bang-Hung Yang; Bing-Wen Soong
Journal:  J Neurol       Date:  2007-04-30       Impact factor: 4.849

3.  Striatal blood flow, glucose metabolism and 18F-dopa uptake: difference in Parkinson's disease and atypical parkinsonism.

Authors:  M Otsuka; Y Ichiya; S Hosokawa; Y Kuwabara; T Tahara; T Fukumura; M Kato; K Masuda; I Goto
Journal:  J Neurol Neurosurg Psychiatry       Date:  1991-10       Impact factor: 10.154

Review 4.  A systematic review of lessons learned from PET molecular imaging research in atypical parkinsonism.

Authors:  Flavia Niccolini; Marios Politis
Journal:  Eur J Nucl Med Mol Imaging       Date:  2016-07-28       Impact factor: 9.236
  4 in total

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