| Literature DB >> 26414350 |
Liang Xiao1, Qiang Feng1,2, Suisha Liang1, Si Brask Sonne2, Zhongkui Xia1, Xinmin Qiu1, Xiaoping Li1, Hua Long3, Jianfeng Zhang1, Dongya Zhang1, Chuan Liu1, Zhiwei Fang1, Joyce Chou3, Jacob Glanville3, Qin Hao2, Dorota Kotowska2, Camilla Colding2, Tine Rask Licht4, Donghai Wu5, Jun Yu6, Joseph Jao Yiu Sung6, Qiaoyi Liang6, Junhua Li1, Huijue Jia1, Zhou Lan1, Valentina Tremaroli7, Piotr Dworzynski8, H Bjørn Nielsen8, Fredrik Bäckhed7,9, Joël Doré10,11, Emmanuelle Le Chatelier11, S Dusko Ehrlich11,12, John C Lin3, Manimozhiyan Arumugam1,9, Jun Wang1,2,13,14, Lise Madsen1,2,15, Karsten Kristiansen1,2.
Abstract
We established a catalog of the mouse gut metagenome comprising ∼2.6 million nonredundant genes by sequencing DNA from fecal samples of 184 mice. To secure high microbiome diversity, we used mouse strains of diverse genetic backgrounds, from different providers, kept in different housing laboratories and fed either a low-fat or high-fat diet. Similar to the human gut microbiome, >99% of the cataloged genes are bacterial. We identified 541 metagenomic species and defined a core set of 26 metagenomic species found in 95% of the mice. The mouse gut microbiome is functionally similar to its human counterpart, with 95.2% of its Kyoto Encyclopedia of Genes and Genomes (KEGG) orthologous groups in common. However, only 4.0% of the mouse gut microbial genes were shared (95% identity, 90% coverage) with those of the human gut microbiome. This catalog provides a useful reference for future studies.Entities:
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Year: 2015 PMID： 26414350 DOI： 10.1038/nbt.3353
Source DB: PubMed Journal: Nat Biotechnol ISSN： 1087-0156 Impact factor: 54.908