Literature DB >> 26414153

Cellular signaling pathways implicated in metastasis of colorectal cancer and the associated targeted agents.

Xuan Liu1, Qing Ji1, Zhongze Fan2, Qi Li1.   

Abstract

Colorectal cancer (CRC) is the third leading cancer worldwide and CRC-related death is mainly attributed to metastasis. Many cellular signaling pathways have been demonstrated to be aberrant in colorectal tumors, and some of them lead to the acquisition of malignant phenotypes. Therefore, the evaluation of signaling pathways implicated in CRC metastasis is urgent for further understanding of CRC progression and pharmacotherapy. This review focuses on several novel cellular signaling pathways associated with CRC metastasis, including Wnt/β-catenin, p53, COX, TGF-β/Smad, NF-κB, Notch, VEGF and JAKs/STAT3 signaling pathways. Targeted agents developed based on these pathways are also briefly discussed.

Entities:  

Keywords:  colorectal cancer; metastasis; molecular mechanisms; signaling pathways; therapeutic agents

Mesh：

Year:  2015        PMID： 26414153     DOI： 10.2217/fon.15.235

Source DB:  PubMed          Journal:  Future Oncol        ISSN： 1479-6694            Impact factor:   3.404


  12 in total

1.  Impact of GFRA1 gene reactivation by DNA demethylation on prognosis of patients with metastatic colon cancer.

Authors:  Wan-Ru Ma; Peng Xu; Zhao-Jun Liu; Jing Zhou; Lian-Kun Gu; Jun Zhang; Da-Jun Deng
Journal:  World J Gastroenterol       Date:  2020-01-14       Impact factor: 5.742

Review 2.  Targeting key transcriptional factor STAT3 in colorectal cancer.

Authors:  Gayathri Chalikonda; Hoomin Lee; Aliya Sheik; Yun Suk Huh
Journal:  Mol Cell Biochem       Date:  2021-04-18       Impact factor: 3.396

3.  The synergistic anti-proliferative effect of the combination of diosmin and BEZ-235 (dactolisib) on the HCT-116 colorectal cancer cell line occurs through inhibition of the PI3K/Akt/mTOR/NF-κB axis.

Authors:  Maged W Helmy; Asser I Ghoneim; Mohamed A Katary; Rana K Elmahdy
Journal:  Mol Biol Rep       Date:  2020-02-22       Impact factor: 2.316

4.  Germline INDELs and CNVs in a cohort of colorectal cancer patients: their characteristics, associations with relapse-free survival time, and potential time-varying effects on the risk of relapse.

Authors:  Salem Werdyani; Yajun Yu; Georgia Skardasi; Jingxiong Xu; Konstantin Shestopaloff; Wei Xu; Elizabeth Dicks; Jane Green; Patrick Parfrey; Yildiz E Yilmaz; Sevtap Savas
Journal:  Cancer Med       Date:  2017-05-23       Impact factor: 4.452

5.  JianPi JieDu Recipe Inhibits Epithelial-to-Mesenchymal Transition in Colorectal Cancer through TGF-β/Smad Mediated Snail/E-Cadherin Expression.

Authors:  Xuan Liu; Qing Ji; Wanli Deng; Ni Chai; Yuanyuan Feng; Lihong Zhou; Hua Sui; Chunpu Li; Xiaoting Sun; Qi Li
Journal:  Biomed Res Int       Date:  2017-02-16       Impact factor: 3.411

6.  A novel FOXM1 isoform, FOXM1D, promotes epithelial-mesenchymal transition and metastasis through ROCKs activation in colorectal cancer.

Authors:  X Zhang; L Zhang; Y Du; H Zheng; P Zhang; Y Sun; Y Wang; J Chen; P Ding; N Wang; C Yang; T Huang; X Yao; Q Qiao; H Gu; G Cai; S Cai; X Zhou; W Hu
Journal:  Oncogene       Date:  2016-07-11       Impact factor: 9.867

Review 7.  Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells?

Authors:  Wolfgang Eberhardt; Usman Nasrullah; Kristina Haeussler
Journal:  Cells       Date:  2019-07-30       Impact factor: 6.600

8.  Turmeric Is Therapeutic in Vivo on Patient-Derived Colorectal Cancer Xenografts: Inhibition of Growth, Metastasis, and Tumor Recurrence.

Authors:  Mingyue Li; Grace Gar-Lee Yue; Lianxiang Luo; Stephen Kwok-Wing Tsui; Kwok-Pui Fung; Simon Siu-Man Ng; Clara Bik-San Lau
Journal:  Front Oncol       Date:  2021-01-19       Impact factor: 6.244

9.  Inositol Hexaphosphate and Inositol Inhibit Colorectal Cancer Metastasis to the Liver in BALB/c Mice.

Authors:  Min Fu; Yang Song; Zhaoxia Wen; Xingyi Lu; Lianhua Cui
Journal:  Nutrients       Date:  2016-05-12       Impact factor: 5.717

10.  Quince peel polyphenolic extract blocks human colon adenocarcinoma LS174 cell growth and potentiates 5-fluorouracil efficacy.

Authors:  Ichrak Riahi-Chebbi; Meriam Haoues; Makram Essafi; Ons Zakraoui; Sami Fattouch; Habib Karoui; Khadija Essafi-Benkhadir
Journal:  Cancer Cell Int       Date:  2016-02-02       Impact factor: 5.722
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