Jingbo Niu1, David T Felson2, Tuhina Neogi1, Michael C Nevitt3, Ali Guermazi4, Frank Roemer5, Cora E Lewis6, James Torner7, Yuqing Zhang1. 1. Boston University School of Medicine, Boston, Massachusetts. 2. Boston University School of Medicine, Boston, Massachusetts, and University of Manchester, Manchester, UK. 3. University of California, San Francisco. 4. Boston University School of Medicine and Boston Core Imaging Lab, LLC, Boston, Massachusetts. 5. Boston University School of Medicine and Boston Core Imaging Lab, LLC, Boston, Massachusetts, and University of Erlangen-Nuremberg, Erlangen, Germany. 6. University of Alabama School of Medicine, Birmingham. 7. University of Iowa, Iowa City.
Abstract
OBJECTIVE: To identify patterns of coexisting lesions seen on magnetic resonance imaging (MRI) in knees that are free of radiographic osteoarthritis (OA) and to examine the relationship of these MRI-detected lesions to incident OA. METHODS: Study subjects were individuals enrolled in the Multicenter Osteoarthritis Study, a prospective cohort study. In each subject, 1 knee in which radiographic OA was absent in both the tibiofemoral and patellofemoral joints at baseline was selected for study, with followup for 84 months. We used a novel approach, latent class analysis, to group the constellation of MRI lesions in each joint, i.e., cartilage damage, bone marrow lesion, meniscal tear, meniscal extrusion, synovitis, and effusion, into a manageable number of subgroups. The association of these subgroups with incident radiographic OA in the same joint was assessed using logistic regression. RESULTS: Among 885 eligible knees (203 with incident disease in the tibiofemoral joint, 64 with incident disease in the patellofemoral joint), 4 latent subgroups in the tibiofemoral joint were identified (described briefly as minimal lesions, mild lesions, moderate lesions [but limited meniscal lesions], and severe lesions). The odds ratios of incident tibiofemoral joint OA in the latter 3 subgroups (compared to the knees with minimal lesions as the referent) were 5.6, 1.8, and 5.0, respectively. A similar set of 4 subgroups in the patellofemoral joint was identified, except that the fourth subgroup had limited meniscal lesions. The odds ratios of incident disease in the patellofemoral joint were 3.8, 5.1, and 13.7 in the subgroups with mild lesions, moderate lesions, and severe lesions, respectively. CONCLUSION: Different patterns of coexisting MRI lesions, which have different implications with regard to risk of knee OA, were identified. Meniscal damage seemed to play a different role in the development of incident disease in tibiofemoral versus patellofemoral joints.
OBJECTIVE: To identify patterns of coexisting lesions seen on magnetic resonance imaging (MRI) in knees that are free of radiographic osteoarthritis (OA) and to examine the relationship of these MRI-detected lesions to incident OA. METHODS: Study subjects were individuals enrolled in the Multicenter Osteoarthritis Study, a prospective cohort study. In each subject, 1 knee in which radiographic OA was absent in both the tibiofemoral and patellofemoral joints at baseline was selected for study, with followup for 84 months. We used a novel approach, latent class analysis, to group the constellation of MRI lesions in each joint, i.e., cartilage damage, bone marrow lesion, meniscal tear, meniscal extrusion, synovitis, and effusion, into a manageable number of subgroups. The association of these subgroups with incident radiographic OA in the same joint was assessed using logistic regression. RESULTS: Among 885 eligible knees (203 with incident disease in the tibiofemoral joint, 64 with incident disease in the patellofemoral joint), 4 latent subgroups in the tibiofemoral joint were identified (described briefly as minimal lesions, mild lesions, moderate lesions [but limited meniscal lesions], and severe lesions). The odds ratios of incident tibiofemoral joint OA in the latter 3 subgroups (compared to the knees with minimal lesions as the referent) were 5.6, 1.8, and 5.0, respectively. A similar set of 4 subgroups in the patellofemoral joint was identified, except that the fourth subgroup had limited meniscal lesions. The odds ratios of incident disease in the patellofemoral joint were 3.8, 5.1, and 13.7 in the subgroups with mild lesions, moderate lesions, and severe lesions, respectively. CONCLUSION: Different patterns of coexisting MRI lesions, which have different implications with regard to risk of knee OA, were identified. Meniscal damage seemed to play a different role in the development of incident disease in tibiofemoral versus patellofemoral joints.
Authors: David T Felson; Michael C Nevitt; Mei Yang; Margaret Clancy; Jingbo Niu; James C Torner; C Elizabeth Lewis; Piran Aliabadi; Burton Sack; Charles McCulloch; Yuqing Zhang Journal: J Rheumatol Date: 2008-09-15 Impact factor: 4.666
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Authors: F W Roemer; A Guermazi; M K Javaid; J A Lynch; J Niu; Y Zhang; D T Felson; C E Lewis; J Torner; M C Nevitt Journal: Ann Rheum Dis Date: 2008-10-01 Impact factor: 19.103
Authors: C G Peterfy; A Guermazi; S Zaim; P F J Tirman; Y Miaux; D White; M Kothari; Y Lu; K Fye; S Zhao; H K Genant Journal: Osteoarthritis Cartilage Date: 2004-03 Impact factor: 6.576
Authors: F W Roemer; A Guermazi; D J Hunter; J Niu; Y Zhang; M Englund; M K Javaid; J A Lynch; A Mohr; J Torner; C E Lewis; M C Nevitt; D T Felson Journal: Osteoarthritis Cartilage Date: 2008-10-17 Impact factor: 6.576
Authors: L Sharma; M Hochberg; M Nevitt; A Guermazi; F Roemer; M D Crema; C Eaton; R Jackson; K Kwoh; J Cauley; O Almagor; J S Chmiel Journal: Osteoarthritis Cartilage Date: 2017-02-14 Impact factor: 6.576
Authors: Frank W Roemer; Mohamed Jarraya; Jamie E Collins; C Kent Kwoh; Daichi Hayashi; David J Hunter; Ali Guermazi Journal: Skeletal Radiol Date: 2022-09-26 Impact factor: 2.128
Authors: Dawei Xu; Jan van der Voet; Nils M Hansson; Stefan Klein; Edwin H G Oei; Femke Wagner; Sebastia M A Bierma-Zeinstra; Jos Runhaar Journal: Rheumatology (Oxford) Date: 2021-03-02 Impact factor: 7.580