Shahnaz Miri1, Sofya Glazman1, Leland Mylin1, Ivan Bodis-Wollner2. 1. Department of Neurology, SUNY Downstate Medical Center, 450 Clarkson Ave, MSC 1213, Brooklyn, NY 11203, USA. 2. Department of Neurology, SUNY Downstate Medical Center, 450 Clarkson Ave, MSC 1213, Brooklyn, NY 11203, USA; Department of Ophthalmology, SUNY Downstate Medical Center, 450 Clarkson Ave, MSC 1213, Brooklyn, NY 11203, USA. Electronic address: ivan.bodis-wollner@downstate.edu.
Abstract
BACKGROUND: Impaired vision and remodeled foveal pit have been demonstrated in Parkinson's disease (PD) patients using different techniques. METHODS: Ten PD (20 eyes) and eight healthy controls (HC) subjects (16 eyes) were enrolled. Subjects were evaluated for N70 and P100 latencies using two-channel VEP with pattern reversal and on/off pattern; Contrast sensitivity (CS) using Pelli-Robson chart; macular thickness measured using Zeiss-HD optical coherence tomography (OCT). RESULTS: PD patients had a significantly delayed N70 (reversal pattern) and P100 (on/off pattern), lower CS score, and decreased retinal thickness at temporal 1.5-2.5 mm from the foveola. N70 latency was negatively correlated with CS (R = -0.419, P = 0.01) and average GCL-IPL thickness (R = -0.529, P = 0.001). CS was positively correlated with parafoveal thickness (R = 0.490, P = 0.002). A combination of parafoveal thickness and CS score yielded an AUC of 0.784 for PD discrimination which increased to 0.844 when combined with N70 and P100 measures. CONCLUSION: A combination of pattern reversal VEP latency, CS score, and inner retinal foveal thickness measures has a high diagnostic yield for PD.
BACKGROUND: Impaired vision and remodeled foveal pit have been demonstrated in Parkinson's disease (PD) patients using different techniques. METHODS: Ten PD (20 eyes) and eight healthy controls (HC) subjects (16 eyes) were enrolled. Subjects were evaluated for N70 and P100 latencies using two-channel VEP with pattern reversal and on/off pattern; Contrast sensitivity (CS) using Pelli-Robson chart; macular thickness measured using Zeiss-HD optical coherence tomography (OCT). RESULTS:PDpatients had a significantly delayed N70 (reversal pattern) and P100 (on/off pattern), lower CS score, and decreased retinal thickness at temporal 1.5-2.5 mm from the foveola. N70 latency was negatively correlated with CS (R = -0.419, P = 0.01) and average GCL-IPL thickness (R = -0.529, P = 0.001). CS was positively correlated with parafoveal thickness (R = 0.490, P = 0.002). A combination of parafoveal thickness and CS score yielded an AUC of 0.784 for PD discrimination which increased to 0.844 when combined with N70 and P100 measures. CONCLUSION: A combination of pattern reversal VEP latency, CS score, and inner retinal foveal thickness measures has a high diagnostic yield for PD.
Authors: Isabel Ortuño-Lizarán; Thomas G Beach; Geidy E Serrano; Douglas G Walker; Charles H Adler; Nicolás Cuenca Journal: Mov Disord Date: 2018-05-08 Impact factor: 10.338
Authors: Eduardo Maria Normando; Benjamin Michael Davis; Lies De Groef; Shereen Nizari; Lisa A Turner; Nivedita Ravindran; Milena Pahlitzsch; Jonathan Brenton; Giulia Malaguarnera; Li Guo; Satyanarayana Somavarapu; Maria Francesca Cordeiro Journal: Acta Neuropathol Commun Date: 2016-08-18 Impact factor: 7.801
Authors: Carlos E Mendoza-Santiesteban; Iñigo Gabilondo; Jose Alberto Palma; Lucy Norcliffe-Kaufmann; Horacio Kaufmann Journal: Front Neurol Date: 2017-05-24 Impact factor: 4.003
Authors: Carlijn D J M Borm; Katarzyna Smilowska; Nienke M de Vries; Bastiaan R Bloem; Thomas Theelen Journal: J Parkinsons Dis Date: 2019 Impact factor: 5.568
Authors: Rimona S Weil; Anette E Schrag; Jason D Warren; Sebastian J Crutch; Andrew J Lees; Huw R Morris Journal: Brain Date: 2016-11-01 Impact factor: 15.255