Ellen M Smith1, Vin Tangpricha. 1. aNutrition and Health Sciences Graduate Program, Laney Graduate School, Emory University bDivision of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta cAtlanta VA Medical Center, Decatur, Georgia, USA.
Abstract
PURPOSE OF REVIEW: The current review highlights recent findings in the emerging association between vitamin D and anemia through discussion of mechanistic studies, epidemiologic studies, and clinical trials. RECENT FINDINGS: Vitamin D has previously been found to be associated with anemia in various healthy and diseased populations. Recent studies indicate that the association may differ between race and ethnic groups and is likely specific to anemia of inflammation. The mechanism underlying this association involves the reduction of proinflammatory cytokines by vitamin D and the direct suppression of hepcidin mRNA transcription. There is also evidence that vitamin D may be protective against anemia by supporting erythropoiesis. Other calciotropic hormones including fibroblast growth factor 23, and parathyroid hormone have also been found to be associated with iron homeostasis and erythropoiesis. SUMMARY: Recent advances in our understanding of the association between vitamin D and anemia suggest that maintenance of sufficient vitamin D status may be important in preventing anemia, particularly in diseases characterized by inflammation. Early clinical trials have been promising, but further research is needed to define the efficacy of vitamin D as a future approach for the treatment of anemia.
PURPOSE OF REVIEW: The current review highlights recent findings in the emerging association between vitamin D and anemia through discussion of mechanistic studies, epidemiologic studies, and clinical trials. RECENT FINDINGS:Vitamin D has previously been found to be associated with anemia in various healthy and diseased populations. Recent studies indicate that the association may differ between race and ethnic groups and is likely specific to anemia of inflammation. The mechanism underlying this association involves the reduction of proinflammatory cytokines by vitamin D and the direct suppression of hepcidin mRNA transcription. There is also evidence that vitamin D may be protective against anemia by supporting erythropoiesis. Other calciotropic hormones including fibroblast growth factor 23, and parathyroid hormone have also been found to be associated with iron homeostasis and erythropoiesis. SUMMARY: Recent advances in our understanding of the association between vitamin D and anemia suggest that maintenance of sufficient vitamin D status may be important in preventing anemia, particularly in diseases characterized by inflammation. Early clinical trials have been promising, but further research is needed to define the efficacy of vitamin D as a future approach for the treatment of anemia.
Authors: Meredith A Atkinson; Michal L Melamed; Juhi Kumar; Cindy N Roy; Edgar R Miller; Susan L Furth; Jeffrey J Fadrowski Journal: J Pediatr Date: 2013-10-08 Impact factor: 4.406
Authors: Ellen M Smith; Jessica A Alvarez; Malcolm D Kearns; Li Hao; John H Sloan; Robert J Konrad; Thomas R Ziegler; Susu M Zughaier; Vin Tangpricha Journal: Clin Nutr Date: 2016-06-27 Impact factor: 7.324
Authors: Stefan Pilz; Nicolas Verheyen; Martin R Grübler; Andreas Tomaschitz; Winfried März Journal: Nat Rev Cardiol Date: 2016-05-06 Impact factor: 32.419
Authors: Meredith A Atkinson; Stephen P Juraschek; Michael S Bertenthal; Barbara Detrick; Susan L Furth; Edgar R Miller Journal: Pediatr Nephrol Date: 2016-12-24 Impact factor: 3.714
Authors: Ellen M Smith; Jennifer L Jones; Jenny E Han; Jessica A Alvarez; John H Sloan; Robert J Konrad; Susu M Zughaier; Greg S Martin; Thomas R Ziegler; Vin Tangpricha Journal: JPEN J Parenter Enteral Nutr Date: 2017-12-11 Impact factor: 4.016