Literature DB >> 26412862

Of Heart & Kidneys: Hands-On Activities for Demonstrating Organ Function & Repair.

Robert M Kao1.   

Abstract

A major challenge in teaching organ development and disease is deconstructing a complex choreography of molecular and cellular changes over time into a linear stepwise process for students. As an entry toward learning developmental concepts, I propose two inexpensive hands-on activities to help facilitate learning of (1) how to identify defects in heart and kidneys and (2) what evolutionarily conserved strategies from organ development can be applied to understand how to repair these defects. The ease of assembling these activities, combined with traffic flow as a metaphor for physiological function of heart and kidneys, provides students the opportunity to explore and discover biological concepts in organ formation and disease.

Entities:  

Keywords:  Organogenesis; heart; hydronephrosis; kidney; lumopathies; stenosis

Year:  2014        PMID: 26412862      PMCID: PMC4582784          DOI: 10.1525/abt.2014.76.8.10

Source DB:  PubMed          Journal:  Am Biol Teach        ISSN: 0002-7685            Impact factor:   0.342


  4 in total

1.  Complex cell rearrangements during intersegmental vessel sprouting and vessel fusion in the zebrafish embryo.

Authors:  Yannick Blum; Heinz-Georg Belting; Elin Ellertsdottir; Lukas Herwig; Florian Lüders; Markus Affolter
Journal:  Dev Biol       Date:  2008-02-13       Impact factor: 3.582

Review 2.  The luminal connection: from animal development to lumopathies.

Authors:  Robert M Kao
Journal:  Organogenesis       Date:  2013-04-01       Impact factor: 2.500

3.  Invasion of distal nephron precursors associates with tubular interconnection during nephrogenesis.

Authors:  Robert M Kao; Aleksandr Vasilyev; Atsushi Miyawaki; Iain A Drummond; Andrew P McMahon
Journal:  J Am Soc Nephrol       Date:  2012-08-16       Impact factor: 10.121

4.  Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice.

Authors:  Ian Chia; David Grote; Michael Marcotte; Ekaterina Batourina; Cathy Mendelsohn; Maxime Bouchard
Journal:  Development       Date:  2011-05       Impact factor: 6.868

  4 in total

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