Literature DB >> 26412842

Does general practice deliver safe primary care to people living with HIV? A case-notes review.

Rosie Wellesley1, Alice Whittle2, Jose Figueroa2, Jane Anderson3, Richard Castles4, Kambiz Boomla1, Chris Griffiths1, Werner Leber1.   

Abstract

BACKGROUND: Safe care in general practice for people living with HIV requires early diagnosis of undetected infection and safe co-prescribing with antiretroviral therapy (ART). AIM: To evaluate safe co-prescribing in general practice patients who are taking ART, and to describe missed diagnostic opportunities for undiagnosed HIV infection in primary care. DESIGN AND
SETTING: Retrospective case-notes review in general practices within NHS City and Hackney Primary Care Trust (PCT), London, UK.
METHOD: All general practices in NHS City and Hackney PCT were invited to participate. Patients known to be HIV positive were identified using Read Codes. Each practice undertook retrospective case-notes reviews on specialist correspondence, coding of ART, prescribing of common contraindicated drug pairings, and missed opportunities for HIV diagnosis.
RESULTS: In total, 31/44 (70.5%) practices participated, and 1022 people living with HIV were identified. Practices had received HIV clinic letters for 698 of those 1022 (68.3%) patients in the previous 12 months. Of the 787 patients known to be prescribed ART, only 413 (52.5%) had correct drug codes recorded; 32/787 (4.1%) were receiving specified contraindicated drug pairings. In total, 89 patients were eligible for their case-notes to undergo a retrospective review of occurrences that took place pre-diagnosis. In the 2 years preceding diagnosis, these 89 had attended 716 face-to-face GP consultations, of which 123 (17.2%) were for indicator conditions. Fifty-one of these patients (57.3%) presented at least once with an indicator condition (interquartile range 1-3; median 2).
CONCLUSION: In a large-scale evaluation of GP records of people living with HIV, gaps in ART recording and co-prescribing were identified, and evidence demonstrated missed opportunities for diagnosis within general practice. Specialists and generalists must communicate better to enhance safe prescribing and reduce delayed diagnosis. © British Journal of General Practice 2015.

Entities:  

Keywords:  HIV; delayed diagnosis; drug interactions; general practice; inappropriate prescribing

Mesh:

Substances:

Year:  2015        PMID: 26412842      PMCID: PMC4582878          DOI: 10.3399/bjgp15X686905

Source DB:  PubMed          Journal:  Br J Gen Pract        ISSN: 0960-1643            Impact factor:   5.386


  16 in total

1.  Public attitudes towards opt-out testing for HIV in primary care: a qualitative study.

Authors:  Simon Glew; Alex Pollard; Leila Hughes; Carrie Llewellyn
Journal:  Br J Gen Pract       Date:  2014-02       Impact factor: 5.386

2.  HIV diagnoses and missed opportunities. Results of the British HIV Association (BHIVA) National Audit 2010.

Authors:  Simon Ellis; Hilary Curtis; Edmund L C Ong
Journal:  Clin Med (Lond)       Date:  2012-10       Impact factor: 2.659

Review 3.  A review of medication incidents reported to the National Reporting and Learning System in England and Wales over 6 years (2005-2010).

Authors:  David H Cousins; David Gerrett; Bruce Warner
Journal:  Br J Clin Pharmacol       Date:  2012-10       Impact factor: 4.335

4.  Promotion of rapid testing for HIV in primary care (RHIVA2): a cluster-randomised controlled trial.

Authors:  Werner Leber; Heather McMullen; Jane Anderson; Nadine Marlin; Andreia C Santos; Stephen Bremner; Kambiz Boomla; Sally Kerry; Danna Millett; Sifiso Mguni; Sarah Creighton; Jose Figueroa; Richard Ashcroft; Graham Hart; Valerie Delpech; Alison Brown; Graeme Rooney; Maria Sampson; Adrian Martineau; Fern Terris-Prestholt; Chris Griffiths
Journal:  Lancet HIV       Date:  2015-04-28       Impact factor: 12.767

5.  Missed opportunities for diagnosing primary HIV infection.

Authors:  D Sudarshi; D Pao; G Murphy; J Parry; G Dean; M Fisher
Journal:  Sex Transm Infect       Date:  2007-10-30       Impact factor: 3.519

Review 6.  Antiretroviral drug interactions: often unrecognized, frequently unavoidable, sometimes unmanageable.

Authors:  Kay Seden; David Back; Saye Khoo
Journal:  J Antimicrob Chemother       Date:  2009-04-27       Impact factor: 5.790

7.  Missed opportunities for earlier HIV diagnosis within primary and secondary healthcare settings in the UK.

Authors:  Fiona M Burns; Anne M Johnson; James Nazroo; Jonathan Ainsworth; Jane Anderson; Ade Fakoya; Ibidun Fakoya; Andy Hughes; Eva Jungmann; S Tariq Sadiq; Ann K Sullivan; Kevin A Fenton
Journal:  AIDS       Date:  2008-01-02       Impact factor: 4.177

8.  Feasibility and acceptability of offering rapid HIV tests to patients registering with primary care in London (UK): a pilot study.

Authors:  A Prost; C J Griffiths; J Anderson; D Wight; G J Hart
Journal:  Sex Transm Infect       Date:  2009-05-31       Impact factor: 3.519

9.  Assessing the predictive value of HIV indicator conditions in general practice: a case-control study using the THIN database.

Authors:  Sarah Damery; Linda Nichols; Roger Holder; Ronan Ryan; Sue Wilson; Sally Warmington; Helen Stokes-Lampard; Kaveh Manavi
Journal:  Br J Gen Pract       Date:  2013-06       Impact factor: 5.386

10.  Auditing national HIV guidelines and policies: The United Kingdom CD4 Surveillance Scheme.

Authors:  Alison E Brown; Meaghan M Kall; Ruth D Smith; Zheng Yin; Alan Hunter; Alan Hunter; Valerie C Delpech
Journal:  Open AIDS J       Date:  2012-09-07
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  7 in total

1.  Patient safety research in primary care: where are we now?

Authors:  Alison Cooper; Antony Chuter
Journal:  Br J Gen Pract       Date:  2015-12       Impact factor: 5.386

2.  Predictors of human immunodeficiency virus (HIV) infection in primary care among adults living in developed countries: a systematic review.

Authors:  Benhildah N Rumbwere Dube; Tom P Marshall; Ronan P Ryan; Modupe Omonijo
Journal:  Syst Rev       Date:  2018-06-02

3.  Evaluation of an educational intervention to increase HIV-testing in high HIV prevalence general practices: a pilot feasibility stepped-wedged randomised controlled trial.

Authors:  Charlotte F Davies; Joanna M Kesten; Mark Gompels; Jeremy Horwood; Megan Crofts; Annette Billing; Charlotte Chick; Margaret T May
Journal:  BMC Fam Pract       Date:  2018-12-13       Impact factor: 2.497

4.  Qualitative evaluation of a pilot educational intervention to increase primary care HIV-testing.

Authors:  Joanna M Kesten; Charlotte F Davies; Mark Gompels; Megan Crofts; Annette Billing; Margaret T May; Jeremy Horwood
Journal:  BMC Fam Pract       Date:  2019-05-31       Impact factor: 2.497

5.  A Case Report of Multiclass HIV Drug-Resistance After an Inappropriate Switch of ARVs with Persistent Unsuppressed Viral Load.

Authors:  Mireille A Mpalang Kakubu; Mukebayi Kalonji; Patrick D M C Katoto
Journal:  J Int Assoc Provid AIDS Care       Date:  2022 Jan-Dec

6.  Evaluating the impact of post-trial implementation of RHIVA nurse-led HIV screening on HIV testing, diagnosis and earlier diagnosis in general practice in London, UK.

Authors:  Werner Leber; Jasmina Panovska-Griffiths; Peter Martin; Stephen Morris; Estela Capelas Barbosa; Claudia Estcourt; Jane Hutchinson; Maryam Shahmanesh; Farah El-Shogri; Kambiz Boomla; Valerie Delpech; Sarah Creighton; Jane Anderson; Jose Figueroa; Chris Griffiths
Journal:  EClinicalMedicine       Date:  2020-01-10

7.  Effectiveness and cost-effectiveness of implementing HIV testing in primary care in East London: protocol for an interrupted time series analysis.

Authors:  Werner Leber; Lee Beresford; Claire Nightingale; Estela Capelas Barbosa; Stephen Morris; Farah El-Shogri; Heather McMullen; Kambiz Boomla; Valerie Delpech; Alison Brown; Jane Hutchinson; Vanessa Apea; Merle Symonds; Samantha Gilliham; Sarah Creighton; Maryam Shahmanesh; Naomi Fulop; Claudia Estcourt; Jane Anderson; Jose Figueroa; Chris Griffiths
Journal:  BMJ Open       Date:  2017-12-14       Impact factor: 2.692

  7 in total

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