Antiresorptive Therapies for Osteoporosis.

Osteoporosis is a disease of low bone density, translating to increased fragility and risk for fracture. It is a significant public health problem that is widely undertreated, despite the many options of treatment available. Among these, the most effective are the antiresorptive medications, such as bisphosphonates. There is an abundance of evidence about the efficacy and safety profile of these medications. However, there is mounting evidence that, after 10 years on treatment with a bisphosphonate, patients are at a higher risk of developing some of the serious side effects of atypical femur fractures and osteonecrosis of the jaw.