A Arnarson1, O Gudny Geirsdottir, A Ramel, P V Jonsson, I Thorsdottir. 1. Alfons Ramel, Unit for Nutrition Research, National University Hospital of Iceland, Eiriksgata 29, 101 Reykjavik, Iceland,Telephone: +354-543-8410, Fax: +354-543-4824, Email: alfonsra@hi.is.
Abstract
BACKGROUND: Insulin-like growth factor-1 (IGF-1) is related to the preservation of lean body mass. Its decline during ageing is thought to make old adults more susceptible to sarcopenia and functional dependency. The aim of the present study was to investigate circulating total IGF-1 in old adults who engaged in a 12-weeks of progressive resistance training. DESIGN: Intervention study. SETTING: Community. PARTICIPANTS: Old Icelandic adults (N = 235, 73.7 ± 5.7 years, 58.2% female). INTERVENTION: Twelve-week resistance exercise program (3 times/week; 3 sets, 6-8 repetitions at 75-80% of the 1-repetition maximum) designed to increase strength and muscle mass of major muscle groups. MEASUREMENTS: IGF-1. RESULTS: At baseline IGF-1 was significantly associated with lean body mass and appendicular muscle mass (also when corrected for age, gender and various covariates). After the training IGF-1 decreased significantly from 112.1 ± 35.6 to 106.1 ± 35.2 µg/L during the course of the study. On and individual level, IGF-1 decreased in 59% and increased in 39% of the participants. Changes in IGF-1 were inversely related to changes in lean body mass (rho = -0.176, P = 0.013 ) and appendicular muscle mass (rho = -0.162, P = 0.019) also when corrected for protein intake, age, gender, and other covariates. CONCLUSION: Serum total IGF-1 decreases after 12 weeks of resistance exercise in community dwelling old adults. When looked at IGF-1 changes for participants individually it becomes clear that IGF-1 response to resistances exercise is highly variable. Changes in IGF-1 are negatively related to changes in lean body mass during training, which supports the hypothesis that IGF-1 is redistributed from circulation into tissue during periods of active muscle building.
BACKGROUND:Insulin-like growth factor-1 (IGF-1) is related to the preservation of lean body mass. Its decline during ageing is thought to make old adults more susceptible to sarcopenia and functional dependency. The aim of the present study was to investigate circulating total IGF-1 in old adults who engaged in a 12-weeks of progressive resistance training. DESIGN: Intervention study. SETTING: Community. PARTICIPANTS: Old Icelandic adults (N = 235, 73.7 ± 5.7 years, 58.2% female). INTERVENTION: Twelve-week resistance exercise program (3 times/week; 3 sets, 6-8 repetitions at 75-80% of the 1-repetition maximum) designed to increase strength and muscle mass of major muscle groups. MEASUREMENTS: IGF-1. RESULTS: At baseline IGF-1 was significantly associated with lean body mass and appendicular muscle mass (also when corrected for age, gender and various covariates). After the training IGF-1 decreased significantly from 112.1 ± 35.6 to 106.1 ± 35.2 µg/L during the course of the study. On and individual level, IGF-1 decreased in 59% and increased in 39% of the participants. Changes in IGF-1 were inversely related to changes in lean body mass (rho = -0.176, P = 0.013 ) and appendicular muscle mass (rho = -0.162, P = 0.019) also when corrected for protein intake, age, gender, and other covariates. CONCLUSION: Serum total IGF-1 decreases after 12 weeks of resistance exercise in community dwelling old adults. When looked at IGF-1 changes for participants individually it becomes clear that IGF-1 response to resistances exercise is highly variable. Changes in IGF-1 are negatively related to changes in lean body mass during training, which supports the hypothesis that IGF-1 is redistributed from circulation into tissue during periods of active muscle building.
Authors: Sara M Gregory; Samuel A Headley; Michael Germain; Allan Flyvbjerg; Jan Frystyk; Mary Ann Coughlin; Charles M Milch; Sheila Sullivan; Bradley C Nindl Journal: Growth Horm IGF Res Date: 2011-01-19 Impact factor: 2.372
Authors: Dorien M Zelle; Gerald Klaassen; Edwin van Adrichem; Stephan J L Bakker; Eva Corpeleijn; Gerjan Navis Journal: Nat Rev Nephrol Date: 2017-01-31 Impact factor: 28.314
Authors: Adam J Sterczala; Joseph R Pierce; Brian R Barnes; Maria L Urso; Ronald W Matheny; Dennis E Scofield; Shawn D Flanagan; Carl M Maresh; Edward J Zambraski; William J Kraemer; Bradley C Nindl Journal: J Appl Physiol (1985) Date: 2022-06-09
Authors: Maha Sellami; Wissem Dhahbi; Lawrence D Hayes; Johnny Padulo; Fatma Rhibi; Hanen Djemail; Anis Chaouachi Journal: PLoS One Date: 2017-08-11 Impact factor: 3.240
Authors: Maha Sellami; Nicola Luigi Bragazzi; Maamer Slimani; Lawrence Hayes; Georges Jabbour; Andrea De Giorgio; Benoit Dugué Journal: Int J Environ Res Public Health Date: 2019-05-15 Impact factor: 3.390