Literature DB >> 26412151

GPR43 - A Prototypic Metabolite Sensor Linking Metabolic and Inflammatory Diseases.

Craig I McKenzie1, Charles R Mackay2, Laurence Macia3.   

Abstract

Short-chain fatty acids (SCFAs) are released upon fermentation of dietary fiber by gut bacteria. G protein-coupled receptor 43 (GPR43), a key receptor for SCFAs, is expressed on cell types important for immunity and metabolism. GPR43 modulates both inflammatory and metabolic processes, and is crucial for understanding the pathogenesis of 'Western lifestyle' diseases.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Fiber; GPR43; SCFAs; inflammation; metabolism

Mesh：

Substances：

Year:  2015        PMID： 26412151     DOI： 10.1016/j.tem.2015.07.009

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  11 in total

Review 1.  The microbiome-metabolome crosstalk in the pathogenesis of respiratory fungal diseases.

Authors:  Samuel M Gonçalves; Katrien Lagrou; Cláudio Duarte-Oliveira; Johan A Maertens; Cristina Cunha; Agostinho Carvalho
Journal:  Virulence       Date:  2016-11-07       Impact factor: 5.882

2.  Microbiota Metabolite Short-Chain Fatty Acids Facilitate Mucosal Adjuvant Activity of Cholera Toxin through GPR43.

Authors:  Wenjing Yang; Yi Xiao; Xiangsheng Huang; Feidi Chen; Mingming Sun; Anthony J Bilotta; Leiqi Xu; Yao Lu; Suxia Yao; Qihong Zhao; Zhanju Liu; Yingzi Cong
Journal:  J Immunol       Date:  2019-05-10       Impact factor: 5.422

Review 3.  SCFA Receptors in Pancreatic β Cells: Novel Diabetes Targets?

Authors:  Medha Priyadarshini; Barton Wicksteed; Gary E Schiltz; Annette Gilchrist; Brian T Layden
Journal:  Trends Endocrinol Metab       Date:  2016-04-15       Impact factor: 12.015

Review 4.  Detrimental Impact of Microbiota-Accessible Carbohydrate-Deprived Diet on Gut and Immune Homeostasis: An Overview.

Authors:  Claire Immediato Daïen; Gabriela Veronica Pinget; Jian Kai Tan; Laurence Macia
Journal:  Front Immunol       Date:  2017-05-12       Impact factor: 7.561

5.  The Metabolic Sensor GPR43 Receptor Plays a Role in the Control of Klebsiella pneumoniae Infection in the Lung.

Authors:  Izabela Galvão; Luciana P Tavares; Renan O Corrêa; José Luís Fachi; Vitor Melo Rocha; Marcela Rungue; Cristiana C Garcia; Geovanni Cassali; Caroline M Ferreira; Flaviano S Martins; Sergio C Oliveira; Charles R Mackay; Mauro M Teixeira; Marco Aurélio R Vinolo; Angélica T Vieira
Journal:  Front Immunol       Date:  2018-02-20       Impact factor: 7.561

Review 6.  The Role of Diet in Multiple Sclerosis: Mechanistic Connections and Current Evidence.

Authors:  Ilana Katz Sand
Journal:  Curr Nutr Rep       Date:  2018-09

7.  GPR43 deficiency protects against podocyte insulin resistance in diabetic nephropathy through the restoration of AMPKα activity.

Authors:  Jian Lu; Pei Pei Chen; Jia Xiu Zhang; Xue Qi Li; Gui Hua Wang; Ben Yin Yuan; Si Jia Huang; Xiao Qi Liu; Ting Ting Jiang; Meng Ying Wang; Wen Tao Liu; Xiong Zhong Ruan; Bi Cheng Liu; Kun Ling Ma
Journal:  Theranostics       Date:  2021-03-04       Impact factor: 11.556

Review 8.  The interplay between microbiota and inflammation: lessons from peritonitis and sepsis.

Authors:  Leandro A Lobo; Claudia F Benjamim; Ana Carolina Oliveira
Journal:  Clin Transl Immunology       Date:  2016-07-15

9.  Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43.

Authors:  W Wu; M Sun; F Chen; A T Cao; H Liu; Y Zhao; X Huang; Y Xiao; S Yao; Q Zhao; Z Liu; Y Cong
Journal:  Mucosal Immunol       Date:  2016-12-14       Impact factor: 7.313

10.  GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3.

Authors:  Ye Zhao; Feidi Chen; Wei Wu; Mingming Sun; Anthony J Bilotta; Suxia Yao; Yi Xiao; Xiangsheng Huang; Tonyia D Eaves-Pyles; George Golovko; Yuriy Fofanov; Warren D'Souza; Qihong Zhao; Zhanju Liu; Yingzi Cong
Journal:  Mucosal Immunol       Date:  2018-02-07       Impact factor: 7.313
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