Zhen Wang1, Sara M May2, Suvanee Charoenlap3, Regan Pyle4, Nancy L Ott5, Khaled Mohammed1, Avni Y Joshi6. 1. Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Rochester, Minnesota. 2. Division of Allergic Diseases, Mayo Clinic, Rochester, Minnesota. 3. King Chulalongkorn Memorial Hospital, Bangkok, Thailand. 4. Allergy & Asthma Consultants, St Louis, Missouri. 5. Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota. 6. Division of Allergic Diseases, Mayo Clinic, Rochester, Minnesota; Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address: joshi.avni@mayo.edu.
Abstract
BACKGROUND: Secondhand smoke (SHS) exposure can trigger asthma exacerbations in children. Different studies have linked increased asthma symptoms, health care use, and deaths in children exposed to SHS, but the risk has not been quantified uniformly across studies. OBJECTIVE: To perform a systematic review and meta-analysis to evaluate and quantify asthma severity and health care use from SHS exposure in children. METHODS: A systematic review was undertaken to assess the association between asthma severity and SHS in children. Inclusion criteria included studies that evaluated children with SHS exposure and reported outcomes of interest with asthma severity including exacerbations. Random effect models were used to combine the outcomes of interest (hospitalization, emergency department or urgent care visits, severe asthma symptoms, wheeze symptoms, and pulmonary function test results) from the included studies. RESULTS: A total of 1,945 studies were identified and 25 studies met the inclusion criteria. Children with asthma and SHS exposure were twice as likely to be hospitalized for asthma (odds ratio [OR] 1.85, 95% confidence interval [CI] 1.20-2.86, P = .01) than children with asthma but without SHS exposure. SHS exposure also was significantly associated with emergency department or urgent care visits (OR 1.66, 95% CI 1.02-2.69, P = 0.04), wheeze symptoms (OR 1.32, 95% CI 1.24, 1.41, P < .001), and lower ratio of forced expiratory volume in 1 second to forced vital capacity (OR -3.34, 95% CI -5.35 to -1.33, P = .001). CONCLUSION: Children with asthma and SHS exposure are nearly twice as likely to be hospitalized with asthma exacerbation and are more likely to have lower pulmonary function test results.
BACKGROUND: Secondhand smoke (SHS) exposure can trigger asthma exacerbations in children. Different studies have linked increased asthma symptoms, health care use, and deaths in children exposed to SHS, but the risk has not been quantified uniformly across studies. OBJECTIVE: To perform a systematic review and meta-analysis to evaluate and quantify asthma severity and health care use from SHS exposure in children. METHODS: A systematic review was undertaken to assess the association between asthma severity and SHS in children. Inclusion criteria included studies that evaluated children with SHS exposure and reported outcomes of interest with asthma severity including exacerbations. Random effect models were used to combine the outcomes of interest (hospitalization, emergency department or urgent care visits, severe asthma symptoms, wheeze symptoms, and pulmonary function test results) from the included studies. RESULTS: A total of 1,945 studies were identified and 25 studies met the inclusion criteria. Children with asthma and SHS exposure were twice as likely to be hospitalized for asthma (odds ratio [OR] 1.85, 95% confidence interval [CI] 1.20-2.86, P = .01) than children with asthma but without SHS exposure. SHS exposure also was significantly associated with emergency department or urgent care visits (OR 1.66, 95% CI 1.02-2.69, P = 0.04), wheeze symptoms (OR 1.32, 95% CI 1.24, 1.41, P < .001), and lower ratio of forced expiratory volume in 1 second to forced vital capacity (OR -3.34, 95% CI -5.35 to -1.33, P = .001). CONCLUSION:Children with asthma and SHS exposure are nearly twice as likely to be hospitalized with asthma exacerbation and are more likely to have lower pulmonary function test results.
Authors: Tianshi David Wu; Michelle N Eakin; Cynthia S Rand; Emily P Brigham; Gregory B Diette; Nadia N Hansel; Meredith C McCormack Journal: J Public Health Manag Pract Date: 2019 Mar/Apr
Authors: Ryan J Coller; Michelle M Kelly; Mary L Ehlenbach; Evan Goyette; Gemma Warner; Paul J Chung Journal: J Pediatr Date: 2017-12-01 Impact factor: 4.406