Seetha M Tamma1, Barbara Shorter2,3, Khai-Lee Toh4, Robert Moldwin5, Barbara Gordon6. 1. Department of Biomedical Sciences and Chair, School of Health Professions and Nursing, Long Island University (LIU) Post, 720 Northern Blvd., Brookville, NY, 11548, USA. stamma@liu.edu. 2. Department of Nutrition, Long Island University (LIU) Post, 720 Northern Blvd., Brookville, NY, 11548, USA. bshorter@liu.edu. 3. Arthur Smith Institute for Urology, North Shore-LIJ Health System, New Hyde Park, NY, 11042, USA. bshorter@liu.edu. 4. Toh Khai Lee Urology Clinic, Mount Elizabeth Medical Centre, 3 Mount Elizabeth, Singapore, 228510, Singapore. khailee.toh@tohklurology.com. 5. Pelvic Pain Center, Arthur Smith Institute for Urology, Hofstra North Shore-LIJ School of Medicine, North Shore-LIJ Health System, 450 Lakeville Road, Suite M41, New Hyde Park, NY, 11042, USA. rmoldwin@gmail.com. 6. Private Practice, Healthcomm Solutions, 2723 N Lakeharbor Lane, Boise, ID, 83703, USA. bgordon@healthcommsolutions.com.
Abstract
PURPOSE: Studies demonstrate that polyunsaturated fatty acids, fish oils, and alpha-linoleic acid are beneficial anti-inflammatory agents, which suppress inflammatory mediators and their activity. METHODS: This review focuses on the effects of omega-3 fatty acids (O-3FAs) on three primary urologic organs (bladder, kidney, and prostate) and associated conditions such as urolithiasis, kidney transplantation, interstitial cystitis/bladder pain syndrome, bladder cancer, prostate cancer (CaP), and chronic prostatitis/chronic pelvic pain syndrome. RESULTS: The following themes emerged: the potential influence of O-3FA in suppressing urologic inflammation; the supportive role of O-3FA in therapeutic interventions; pro-inflammatory mechanisms of omega-6 fatty acids (O-6FAs) associated with disease progression; and the importance of the optimal ratio of O-6FAs/O-3FAs. CONCLUSIONS: The need for further research on the role of PUFAs in suppressing urological inflammation precipitated.
PURPOSE: Studies demonstrate that polyunsaturated fatty acids, fish oils, and alpha-linoleic acid are beneficial anti-inflammatory agents, which suppress inflammatory mediators and their activity. METHODS: This review focuses on the effects of omega-3 fatty acids (O-3FAs) on three primary urologic organs (bladder, kidney, and prostate) and associated conditions such as urolithiasis, kidney transplantation, interstitial cystitis/bladder pain syndrome, bladder cancer, prostate cancer (CaP), and chronic prostatitis/chronic pelvic pain syndrome. RESULTS: The following themes emerged: the potential influence of O-3FA in suppressing urologic inflammation; the supportive role of O-3FA in therapeutic interventions; pro-inflammatory mechanisms of omega-6 fatty acids (O-6FAs) associated with disease progression; and the importance of the optimal ratio of O-6FAs/O-3FAs. CONCLUSIONS: The need for further research on the role of PUFAs in suppressing urological inflammation precipitated.
Authors: A Braundmeier-Fleming; Nathan T Russell; Wenbin Yang; Megan Y Nas; Ryan E Yaggie; Matthew Berry; Laurie Bachrach; Sarah C Flury; Darlene S Marko; Colleen B Bushell; Michael E Welge; Bryan A White; Anthony J Schaeffer; David J Klumpp Journal: Sci Rep Date: 2016-05-18 Impact factor: 4.379