| Literature DB >> 26411289 |
Koji Atarashi1, Takeshi Tanoue2, Minoru Ando3, Nobuhiko Kamada4, Yuji Nagano2, Seiko Narushima2, Wataru Suda5, Akemi Imaoka3, Hiromi Setoyama3, Takashi Nagamori6, Eiji Ishikawa3, Tatsuichiro Shima3, Taeko Hara3, Shoichi Kado3, Toshi Jinnohara2, Hiroshi Ohno2, Takashi Kondo2, Kiminori Toyooka7, Eiichiro Watanabe2, Shin-Ichiro Yokoyama8, Shunji Tokoro8, Hiroshi Mori8, Yurika Noguchi9, Hidetoshi Morita10, Ivaylo I Ivanov11, Tsuyoshi Sugiyama8, Gabriel Nuñez12, J Gray Camp13, Masahira Hattori5, Yoshinori Umesaki14, Kenya Honda15.
Abstract
Intestinal Th17 cells are induced and accumulate in response to colonization with a subgroup of intestinal microbes such as segmented filamentous bacteria (SFB) and certain extracellular pathogens. Here, we show that adhesion of microbes to intestinal epithelial cells (ECs) is a critical cue for Th17 induction. Upon monocolonization of germ-free mice or rats with SFB indigenous to mice (M-SFB) or rats (R-SFB), M-SFB and R-SFB showed host-specific adhesion to small intestinal ECs, accompanied by host-specific induction of Th17 cells. Citrobacter rodentium and Escherichia coli O157 triggered similar Th17 responses, whereas adhesion-defective mutants of these microbes failed to do so. Moreover, a mixture of 20 bacterial strains, which were selected and isolated from fecal samples of a patient with ulcerative colitis on the basis of their ability to cause a robust induction of Th17 cells in the mouse colon, also exhibited EC-adhesive characteristics.Entities:
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Year: 2015 PMID： 26411289 PMCID： PMC4765954 DOI： 10.1016/j.cell.2015.08.058
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582