Literature DB >> 26410595

Structures for G-Protein-Coupled Receptor Tetramers in Complex with G Proteins.

Arnau Cordomí1, Gemma Navarro2, María S Aymerich3, Rafael Franco4.   

Abstract

G-Protein-coupled receptors (GPCRs) were classically described as monomers. We now appreciate that they also function as homo- and hetero-oligomers, for which structural information is lacking. Here, we use available 3D structures and biochemical considerations to present and evaluate experimentally testable structural models for GPCR oligomers and associated G proteins.
Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Entities:  

Keywords:  GPCR; dimers; heteromer; model; oligomer; structure

Mesh：

Substances：

Year:  2015        PMID： 26410595     DOI： 10.1016/j.tibs.2015.07.007

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  23 in total

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Authors:  Nazish Abdullah; Muheeb Beg; David Soares; Jeremy S Dittman; Timothy E McGraw
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Review 5.  Membrane-Mediated Oligomerization of G Protein Coupled Receptors and Its Implications for GPCR Function.

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Authors:  Daniel Pulido; Verònica Casadó-Anguera; Laura Pérez-Benito; Estefanía Moreno; Arnau Cordomí; Laura López; Antoni Cortés; Sergi Ferré; Leonardo Pardo; Vicent Casadó; Miriam Royo
Journal:  J Med Chem       Date:  2018-10-11       Impact factor: 8.039

8.  Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs.

Authors:  Gemma Navarro; Arnau Cordomí; Monika Zelman-Femiak; Marc Brugarolas; Estefania Moreno; David Aguinaga; Laura Perez-Benito; Antoni Cortés; Vicent Casadó; Josefa Mallol; Enric I Canela; Carme Lluís; Leonardo Pardo; Ana J García-Sáez; Peter J McCormick; Rafael Franco
Journal:  BMC Biol       Date:  2016-04-05       Impact factor: 7.431

Review 9.  Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization.

Authors:  Rafael Franco; Eva Martínez-Pinilla; José L Lanciego; Gemma Navarro
Journal:  Front Pharmacol       Date:  2016-03-31       Impact factor: 5.810

Review 10.  Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders.

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Journal:  Front Neurosci       Date:  2016-09-13       Impact factor: 4.677
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