P Holtrop1, T Swails1, T Riggs2. 1. Department of Pediatrics, William Beaumont Hospital, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA. 2. William Beaumont Hospital Research Institute, Beaumont Children's Hospital, Oakland University William Beaumont School of Medicine, Royal Oak, MI, USA.
Abstract
OBJECTIVE: To determine the prevalence of high TG levels in extremely low birth weight (ELBW) infants and what the risk factors are for high TG levels. STUDY DESIGN: We performed a prospective observational study of triglyceride concentrations in extremely low birth weight infants receiving lipid infusions. Lipid infusions were begun at 0.5 grams/kg/day at age one day and the dose advanced by 0.5 grams/kg/day. Triglyceride concentrations were drawn when the dose reached 1 and 2 grams/kg/day. We compared infants with normal triglyceride levels (≤200 mg/dl) with those with elevated triglyceride levels (>200 mg/dl) with univariate and multivariate analysis. RESULTS: There were 75 infants included in the analysis. Twenty (26.7% , 95% CI = 16.6-36.7%) had triglyceride levels >200 mg/dl. On multiple logistic regression analysis, lower birth weight was associated with the risk of an elevated triglyceride level. Triglyceride levels >200 mg/dl did not predict future mortality or morbidity. CONCLUSION: Elevated TG levels occur commonly in ELBW infants and are associated with a lower birth weight.
OBJECTIVE: To determine the prevalence of high TG levels in extremely low birth weight (ELBW) infants and what the risk factors are for high TG levels. STUDY DESIGN: We performed a prospective observational study of triglyceride concentrations in extremely low birth weight infants receiving lipid infusions. Lipid infusions were begun at 0.5 grams/kg/day at age one day and the dose advanced by 0.5 grams/kg/day. Triglyceride concentrations were drawn when the dose reached 1 and 2 grams/kg/day. We compared infants with normal triglyceride levels (≤200 mg/dl) with those with elevated triglyceride levels (>200 mg/dl) with univariate and multivariate analysis. RESULTS: There were 75 infants included in the analysis. Twenty (26.7% , 95% CI = 16.6-36.7%) had triglyceride levels >200 mg/dl. On multiple logistic regression analysis, lower birth weight was associated with the risk of an elevated triglyceride level. Triglyceride levels >200 mg/dl did not predict future mortality or morbidity. CONCLUSION: Elevated TG levels occur commonly in ELBW infants and are associated with a lower birth weight.
Authors: Giovanni Boscarino; Maria Giulia Conti; Francesca De Luca; Maria Di Chiara; Giorgia Deli; Marco Bianchi; Paola Favata; Viviana Cardilli; Giovanni Di Nardo; Pasquale Parisi; Gianluca Terrin Journal: Nutrients Date: 2021-04-09 Impact factor: 5.717