Maurício Martins Chaoul1, José Reinaldo C Braz1, Lorena Mendes C Lucio1, Márjorie A Golim2, Leandro Gobbo Braz1, Mariana Gobbo Braz3. 1. Faculdade de Medicina de Botucatu, Departamento de Anestesiologia, UNESP - Univ Estadual Paulista, Distrito de Rubião Junior, s/n, Botucatu, SP, 18618-970, Brazil. 2. Faculdade de Medicina de Botucatu, Divisão de Hemocentro, UNESP - Univ Estadual Paulista, Distrito de Rubião Junior, s/n, Botucatu, SP, 18618-970, Brazil. 3. Faculdade de Medicina de Botucatu, Departamento de Anestesiologia, UNESP - Univ Estadual Paulista, Distrito de Rubião Junior, s/n, Botucatu, SP, 18618-970, Brazil. mgbraz@hotmail.com.
Abstract
INTRODUCTION: There is great concern about the possible harmful effects of exposure to volatile anesthetics. The current study aimed at evaluating, for the first time, the effects of occupational exposure to anesthetic gases on physicians who work in operating rooms, by determining several inflammatory cytokines. MATERIALS AND METHODS: Plasma inflammatory cytokines (IL-1β, -6, -8, -10, -12, TNF-α) were investigated in 30 individuals who were allocated into two groups of 15: the exposed group, consisting of operating room medical personnel exposed to a mixture of anesthetic gases for 3 years, and a control group composed of medical personnel not exposed to anesthetic gases. The concentrations of volatile anesthetics were measured in the operating room by means of an infrared portable analyzer RESULTS AND CONCLUSIONS: Our findings suggest an increase of the pro-inflammatory IL-8 (p<0.05) in medical personnel exposed to high concentrations of anesthetic gases, even for a relatively short period.
INTRODUCTION: There is great concern about the possible harmful effects of exposure to volatile anesthetics. The current study aimed at evaluating, for the first time, the effects of occupational exposure to anesthetic gases on physicians who work in operating rooms, by determining several inflammatory cytokines. MATERIALS AND METHODS: Plasma inflammatory cytokines (IL-1β, -6, -8, -10, -12, TNF-α) were investigated in 30 individuals who were allocated into two groups of 15: the exposed group, consisting of operating room medical personnel exposed to a mixture of anesthetic gases for 3 years, and a control group composed of medical personnel not exposed to anesthetic gases. The concentrations of volatile anesthetics were measured in the operating room by means of an infrared portable analyzer RESULTS AND CONCLUSIONS: Our findings suggest an increase of the pro-inflammatory IL-8 (p<0.05) in medical personnel exposed to high concentrations of anesthetic gases, even for a relatively short period.
Authors: Anna M Hejl; Olorunfemi Adetona; David Diaz-Sanchez; Jacqueline D Carter; Adwoa A Commodore; Stephen L Rathbun; Luke P Naeher Journal: J Occup Environ Hyg Date: 2013 Impact factor: 2.155
Authors: Teresa Wrońska-Nofer; Jerzy-Roch Nofer; Jolanta Jajte; Elżbieta Dziubałtowska; Wiesław Szymczak; Wojciech Krajewski; Wojciech Wąsowicz; Konrad Rydzyński Journal: Mutat Res Date: 2011-11-04 Impact factor: 2.433
Authors: S S Salvi; C Nordenhall; A Blomberg; B Rudell; J Pourazar; F J Kelly; S Wilson; T Sandström; S T Holgate; A J Frew Journal: Am J Respir Crit Care Med Date: 2000-02 Impact factor: 21.405
Authors: Patricia V Díaz; Aldo A Gaggero; Ricardo A Pinto; Rossana Mamani; Paola A Uasapud; María Rosa Bono Journal: Rev Med Chil Date: 2013-05 Impact factor: 0.553
Authors: Jarod M Hanson; Lydia J Anderson; Colin M Williams; Patricia Jorquera; Ralph A Tripp Journal: Lab Anim (NY) Date: 2016-08-23 Impact factor: 12.625
Authors: Lorena M C Lucio; Mariana G Braz; Paulo do Nascimento Junior; José Reinaldo C Braz; Leandro G Braz Journal: Braz J Anesthesiol Date: 2017-06-24