Schapoor Hessam1, Michael Sand1, Thilo Gambichler1, Falk G Bechara2. 1. Department of Dermatology, Venereology, and Allergology, Ruhr-University Bochum, Bochum, Germany. 2. Department of Dermatology, Venereology, and Allergology, Ruhr-University Bochum, Bochum, Germany. Electronic address: f.bechara@klinikum-bochum.de.
Abstract
BACKGROUND: Data regarding the association of routinely obtained serum markers of inflammation, namely C-reactive protein (CRP), white blood cell count, and neutrophil count, with disease severity of hidradenitis suppurativa (HS) according to a scoring system have not been reported to our knowledge. OBJECTIVE: We sought to evaluate these inflammatory serum markers for assessing disease severity of HS. METHODS: Medical files of 275 patients who were referred to the outpatient HS center of the Department of Dermatology, Venereology, and Allergology, Ruhr-University Bochum, in 2013 were evaluated retrospectively. RESULTS: CRP levels and neutrophil count significantly differed among Hurley stages I, II and III (P < .0001, P = .0002, respectively). There were significant positive correlations among CRP levels (r = 0.496, P < .0001) and neutrophil count (r = 0.330, P = .0009) with modified Hidradenitis Suppurativa Score. CRP was a significant independent predictor for Hurley stage III (odds ratio 1.077, 95% confidence interval 1.013-1.145, P = .016). CRP and body mass index were significant independent predictors for severe disease according to modified Hidradenitis Suppurativa Score (odds ratio 1.065, 95% confidence interval 1.015-1.117, P = .009; and odds ratio 1.12, 95% confidence interval 1.009-1.243, P = .032, respectively). LIMITATIONS: Files were analyzed retrospectively. CONCLUSION: These inflammatory markers, especially CRP, are effective for assessing the extent of disease severity and the grade of inflammation in patients with HS.
BACKGROUND: Data regarding the association of routinely obtained serum markers of inflammation, namely C-reactive protein (CRP), white blood cell count, and neutrophil count, with disease severity of hidradenitis suppurativa (HS) according to a scoring system have not been reported to our knowledge. OBJECTIVE: We sought to evaluate these inflammatory serum markers for assessing disease severity of HS. METHODS: Medical files of 275 patients who were referred to the outpatient HS center of the Department of Dermatology, Venereology, and Allergology, Ruhr-University Bochum, in 2013 were evaluated retrospectively. RESULTS:CRP levels and neutrophil count significantly differed among Hurley stages I, II and III (P < .0001, P = .0002, respectively). There were significant positive correlations among CRP levels (r = 0.496, P < .0001) and neutrophil count (r = 0.330, P = .0009) with modified Hidradenitis Suppurativa Score. CRP was a significant independent predictor for Hurley stage III (odds ratio 1.077, 95% confidence interval 1.013-1.145, P = .016). CRP and body mass index were significant independent predictors for severe disease according to modified Hidradenitis Suppurativa Score (odds ratio 1.065, 95% confidence interval 1.015-1.117, P = .009; and odds ratio 1.12, 95% confidence interval 1.009-1.243, P = .032, respectively). LIMITATIONS: Files were analyzed retrospectively. CONCLUSION: These inflammatory markers, especially CRP, are effective for assessing the extent of disease severity and the grade of inflammation in patients with HS.
Authors: Ali Alikhan; Christopher Sayed; Afsaneh Alavi; Raed Alhusayen; Alain Brassard; Craig Burkhart; Karen Crowell; Daniel B Eisen; Alice B Gottlieb; Iltefat Hamzavi; Paul G Hazen; Tara Jaleel; Alexa B Kimball; Joslyn Kirby; Michelle A Lowes; Robert Micheletti; Angela Miller; Haley B Naik; Dennis Orgill; Yves Poulin Journal: J Am Acad Dermatol Date: 2019-03-11 Impact factor: 15.487
Authors: Chidubem A V Okeke; Jonathan P Williams; Callyn U Iwuala; Pearl K Igwe; Raveena Khanna; Jessica D Perry; Ginette A Okoye; Angel S Byrd Journal: Front Immunol Date: 2022-03-29 Impact factor: 7.561
Authors: Samuel Der Sarkissian; Schapoor Hessam; Joslyn S Kirby; Michelle A Lowes; Dillon Mintoff; Haley B Naik; Hans Christian Ring; Nisha Suyien Chandran; John W Frew Journal: JAMA Dermatol Date: 2022-03-01 Impact factor: 11.816
Authors: E Delany; G Gormley; R Hughes; S McCarthy; S Kirthi; T Markham; A-M Tobin; M Murphy; B Kirby Journal: J Eur Acad Dermatol Venereol Date: 2017-12-06 Impact factor: 6.166
Authors: D Jiménez-Gallo; R de la Varga-Martínez; L Ossorio-García; C Albarrán-Planelles; C Rodríguez; M Linares-Barrios Journal: Mediators Inflamm Date: 2017-07-10 Impact factor: 4.711