Sunyong Kim1, Sung Keun Park2, Jae-Hong Ryoo3, Joong-Myung Choi4, Hyun Pyo Hong5, Jai Hyung Park6, Young Ju Suh7, Young-Sang Byoun8. 1. Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 2. Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Departments of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea. 3. Departments of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea. Electronic address: armani131@naver.com. 4. Departments of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea. 5. Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 6. Department of Orthopaedic Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea. 7. Institute of Clinical Research, School of Medicine, Inha University, Incheon, Republic of Korea. 8. Departments of Internal Medicine, Bucheon Daesung Hospital, Gyeonggi-do, Republic of Korea.
Abstract
BACKGROUND: Despite accumulating evidence suggesting the clinical association between serum ferritin concentrations and diabetes, it is not clearly identified in other ethnic groups besides western population. This study analyzed a longitudinal relationship between serum ferritin concentration and the risk for diabetes in non-diabetic Korean men. METHODS: This study was composed of a cohort of 30,002 non-diabetic Korean men who participated in medical health check-up program in 2005. They were divided into 4 groups according to their baseline ferritin concentrations (first quartile-fourth quartile) and monitored until 2010. Their incidences and hazard ratios of diabetes were compared among 4 groups according to their baseline ferritin concentrations. RESULTS: While 2655 cases of diabetes newly developed during follow-up, incidence of diabetes increased proportionally to the baseline serum ferritin concentrations. In Cox-proportional hazard model, hazard ratios for diabetes also independently increased according to the baseline serum ferritin concentrations [quartile 1: 1.00 (reference), quartile 2: 1.00 (0.87-1.12), quartile 3: 1.13 (1.00-1.29), quartile 4: 1.18 (1.04-1.34), respectively]. CONCLUSIONS: Increased ferritin concentration was associated with increased risk for diabetes in Korean men. These findings suggest the clinical significance of serum ferritin concentration in the development diabetes.
BACKGROUND: Despite accumulating evidence suggesting the clinical association between serum ferritin concentrations and diabetes, it is not clearly identified in other ethnic groups besides western population. This study analyzed a longitudinal relationship between serum ferritin concentration and the risk for diabetes in non-diabetic Korean men. METHODS: This study was composed of a cohort of 30,002 non-diabetic Korean men who participated in medical health check-up program in 2005. They were divided into 4 groups according to their baseline ferritin concentrations (first quartile-fourth quartile) and monitored until 2010. Their incidences and hazard ratios of diabetes were compared among 4 groups according to their baseline ferritin concentrations. RESULTS: While 2655 cases of diabetes newly developed during follow-up, incidence of diabetes increased proportionally to the baseline serum ferritin concentrations. In Cox-proportional hazard model, hazard ratios for diabetes also independently increased according to the baseline serum ferritin concentrations [quartile 1: 1.00 (reference), quartile 2: 1.00 (0.87-1.12), quartile 3: 1.13 (1.00-1.29), quartile 4: 1.18 (1.04-1.34), respectively]. CONCLUSIONS: Increased ferritin concentration was associated with increased risk for diabetes in Korean men. These findings suggest the clinical significance of serum ferritin concentration in the development diabetes.