Zhen Xu1, Lei Yan1, Wen Liu1, Xinxin Xu1, Miao Li1, Lingling Ding1, Jinlong Ma2, Zi-Jiang Chen1. 1. Center for Reproductive Medicine, Reproductive Hospital Affiliated to Shandong University, Jinan; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan; Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China. 2. Center for Reproductive Medicine, Reproductive Hospital Affiliated to Shandong University, Jinan; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan; Key Laboratory for Reproductive Endocrinology of Ministry of Education, Jinan; Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, People's Republic of China. Electronic address: chenzijiang@hotmail.com.
Abstract
OBJECTIVE: To evaluate the influence of previous ectopic pregnancies (EP) and different EP treatment methods on in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) outcomes. DESIGN: Retrospective cohort study. SETTING: University-based reproductive medicine center. PATIENT(S): Women undergoing 51,268 fresh cycles of IVF-ICSI. INTERVENTION(S): In women who had had an EP before the IVF treatment and women who were diagnosed with fallopian disease without an EP (control group), division into three treatment subgroups: subgroup 1, conservative treatment; subgroup 2, salpingostomy; and subgroup 3 salpingectomy. MAIN OUTCOME MEASURE(S): Estimates of IVF-ICSI outcome and ovarian function based on number of antral follicles and rates of implantation, EP, clinical pregnancy, and delivery. RESULT(S): For the experimental group and the control group, there were no statistically significant differences in the rates of implantation, clinical pregnancy, or delivery. However, the risk of recurrent EP was statistically significantly higher in the experimental group compared with the control group. There were no statistically significant differences in IVF-ICSI outcomes between the three treatment subgroups in terms of the basic antral follicle number or the dominant antral follicle numbers (>1.0 cm) after surgical treatment of EP. CONCLUSION(S): Our results suggest that women with a prior history of EP have a higher recurrence risk of EP after IVF in comparison with women with no history of EP. Previous EP has no effect on the main IVF-ICSI outcomes. For the treatment of EP, salpingostomy and salpingectomy do not statistically significantly affect ovarian function.
OBJECTIVE: To evaluate the influence of previous ectopic pregnancies (EP) and different EP treatment methods on in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) outcomes. DESIGN: Retrospective cohort study. SETTING: University-based reproductive medicine center. PATIENT(S): Women undergoing 51,268 fresh cycles of IVF-ICSI. INTERVENTION(S): In women who had had an EP before the IVF treatment and women who were diagnosed with fallopian disease without an EP (control group), division into three treatment subgroups: subgroup 1, conservative treatment; subgroup 2, salpingostomy; and subgroup 3 salpingectomy. MAIN OUTCOME MEASURE(S): Estimates of IVF-ICSI outcome and ovarian function based on number of antral follicles and rates of implantation, EP, clinical pregnancy, and delivery. RESULT(S): For the experimental group and the control group, there were no statistically significant differences in the rates of implantation, clinical pregnancy, or delivery. However, the risk of recurrent EP was statistically significantly higher in the experimental group compared with the control group. There were no statistically significant differences in IVF-ICSI outcomes between the three treatment subgroups in terms of the basic antral follicle number or the dominant antral follicle numbers (>1.0 cm) after surgical treatment of EP. CONCLUSION(S): Our results suggest that women with a prior history of EP have a higher recurrence risk of EP after IVF in comparison with women with no history of EP. Previous EP has no effect on the main IVF-ICSI outcomes. For the treatment of EP, salpingostomy and salpingectomy do not statistically significantly affect ovarian function.