Literature DB >> 26409040

PPARα regulates tumor progression, foe or friend?

Jiaming Gao1, Shuping Yuan1, Jianhua Jin2, Juanjuan Shi3, Yongzhong Hou4.   

Abstract

PPARα belongs to the peroxisome-proliferator-activated receptors (PPARs) family that consists of PPARα, PPARδ, and PAPRγ. Activation of PPARα by ligands including fatty acids and their derivatives as well as some synthetic compounds regulates tumor progression in various tissues. Activated PPARα inhibits or promotes tumorigenesis depending on the specific tissues, but the molecular mechanism is still unclear. In this review, the recent progress of PPARα regulating tumorigenesis is discussed.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Ligands; PPARα; Tumorigenesis

Mesh：

Substances：

Year:  2015        PMID： 26409040     DOI： 10.1016/j.ejphar.2015.09.027

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  11 in total

1.  Simultaneous Presentation of Multiple Myeloma and Lung Cancer: Case Report and Gene Bioinformatics Analysis.

Authors:  Ping-Ping Xiao; Bing-Qing Luo; Wei Fan; Xu-Yan Chen; Zhi-Gao Dong; Jin-Mei Huang; Yi Zhang; Yong-Quan Chen
Journal:  Front Oncol       Date:  2022-06-13       Impact factor: 5.738

2.  Activation of PPARα by clofibrate sensitizes pancreatic cancer cells to radiation through the Wnt/β-catenin pathway.

Authors:  J Xue; W Zhu; J Song; Y Jiao; J Luo; C Yu; J Zhou; J Wu; M Chen; W-Q Ding; J Cao; S Zhang
Journal:  Oncogene       Date:  2017-10-23       Impact factor: 9.867

Review 3.  Peroxisome Proliferator-Activated Receptor Modulation during Metabolic Diseases and Cancers: Master and Minions.

Authors:  Salvatore Giovanni Vitale; Antonio Simone Laganà; Angela Nigro; Valentina Lucia La Rosa; Paola Rossetti; Agnese Maria Chiara Rapisarda; Sandro La Vignera; Rosita Angela Condorelli; Francesco Corrado; Massimo Buscema; Rosario D'Anna
Journal:  PPAR Res       Date:  2016-12-28       Impact factor: 4.964

4.  A potential common role of the Jumonji C domain-containing 1A histone demethylase and chromatin remodeler ATRX in promoting colon cancer.

Authors:  Xiaomeng Li; Sangphil Oh; Hoogeun Song; Sook Shin; Bin Zhang; Willard M Freeman; Ralf Janknecht
Journal:  Oncol Lett       Date:  2018-09-24       Impact factor: 2.967

5.  PPARα Enhances Cancer Cell Chemotherapy Sensitivity by Autophagy Induction.

Authors:  Mengli You; Jiaming Gao; Jianhua Jin; Yongzhong Hou
Journal:  J Oncol       Date:  2018-11-04       Impact factor: 4.375

6.  Decreased expression of peroxisome proliferator-activated receptor alpha indicates unfavorable outcomes in hepatocellular carcinoma.

Authors:  Yong-Bo Xiao; Shao-Hang Cai; Li-Li Liu; Xia Yang; Jing-Ping Yun
Journal:  Cancer Manag Res       Date:  2018-06-26       Impact factor: 3.989

7.  Integrated multi-omics profiling of nonfunctioning pituitary adenomas.

Authors:  Zhenqing Wei; Cuiqi Zhou; Minghui Li; Ruocheng Huang; Hongjuan Deng; Stephen Shen; Renzhi Wang
Journal:  Pituitary       Date:  2020-11-18       Impact factor: 4.107

8.  PPARα induces cell apoptosis by destructing Bcl2.

Authors:  Jiaming Gao; Qian Liu; Ying Xu; Xin Gong; Runyun Zhang; Chenglin Zhou; Zhaoliang Su; Jianhua Jin; Haifeng Shi; Juanjuan Shi; Yongzhong Hou
Journal:  Oncotarget       Date:  2015-12-29

9.  Y-27632 Increases Sensitivity of PANC-1 Cells to EGCG in Regulating Cell Proliferation and Migration.

Authors:  Xing Liu; Yongyi Bi
Journal:  Med Sci Monit       Date:  2016-10-03

10.  4-phenylbutyric acid promotes hepatocellular carcinoma via initiating cancer stem cells through activation of PPAR-α.

Authors:  Shu-Zhen Chen; Yan Ling; Le-Xing Yu; Yu-Ting Song; Xiao-Fei Chen; Qi-Qi Cao; Han Yu; Can Chen; Jiao-Jiao Tang; Zhe-Cai Fan; Yu-Shan Miao; Ya-Ping Dong; Jun-Yan Tao; Satdarshan P S Monga; Wen Wen; Hong-Yang Wang
Journal:  Clin Transl Med       Date:  2021-04
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