Rezarta Frakulli1, Fabrizio Salvi2, Damiano Balestrini2, Alessandro Parisi2, Marcella Palombarini3, Silvia Cammelli4, Michele Rocca5, Mariacristina Salone5, Alessandra Longhi6, Stefano Ferrari6, Alessio G Morganti4, Giovanni Frezza2. 1. Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy rezarta.frakulli@gmail.com. 2. Radiation Oncology Unit, Bellaria Hospital, Bologna, Italy. 3. Medical Physics Unit, Bellaria Hospital, Bologna, Italy. 4. Radiation Oncology Center, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy. 5. General and Thoracic Surgery, Rizzoli Orthopaedic Institute, Bologna, Italy. 6. Department of Oncology, Rizzoli Orthopaedic Institute, Bologna, Italy.
Abstract
BACKGROUND: The purpose of this study was to evaluate local control and toxicity in a group of patients treated with stereotactic body radiotherapy (SBRT) for lung metastases (LM) from bone and soft tissue sarcomas. PATIENTS AND METHODS: From October 2010 to July 2014, patients with LM from sarcomas not suitable for surgery were treated with daily cone-beam computed tomography-guided SBRT. The dose administered ranged from 30 to 60 Gy in 3-8 fractions. Acute and late toxicity were scored according to Common Terminology Criteria for Adverse Events version 4.0. RESULTS: A total of 24 patients with 68 LM from sarcomas were treated with SBRT. The median follow-up after SBRT was 17 months (range=11-51 months). Two-year actuarial lesion local control and overall survival were 85.9% and 66.4%, respectively. No G3 or greater acute and late toxicities were observed. CONCLUSION: SBRT is a safe and effective treatment for LM from sarcoma and might be used as an alternative option in patients unfit for surgery. Copyright
BACKGROUND: The purpose of this study was to evaluate local control and toxicity in a group of patients treated with stereotactic body radiotherapy (SBRT) for lung metastases (LM) from bone and soft tissue sarcomas. PATIENTS AND METHODS: From October 2010 to July 2014, patients with LM from sarcomas not suitable for surgery were treated with daily cone-beam computed tomography-guided SBRT. The dose administered ranged from 30 to 60 Gy in 3-8 fractions. Acute and late toxicity were scored according to Common Terminology Criteria for Adverse Events version 4.0. RESULTS: A total of 24 patients with 68 LM from sarcomas were treated with SBRT. The median follow-up after SBRT was 17 months (range=11-51 months). Two-year actuarial lesion local control and overall survival were 85.9% and 66.4%, respectively. No G3 or greater acute and late toxicities were observed. CONCLUSION: SBRT is a safe and effective treatment for LM from sarcoma and might be used as an alternative option in patients unfit for surgery. Copyright
Authors: David Boyce-Fappiano; Ethan P Damron; Ahsan Farooqi; Devarati Mitra; Anthony P Conley; Neeta Somaiah; Dejka M Araujo; J Andrew Livingston; Ravin Ratan; Emily Z Keung; Christina L Roland; B Ashleigh Guadagnolo; Andrew J Bishop Journal: Adv Radiat Oncol Date: 2022-02-05