Shaheen Alanee1, Danuta Dynda2, Bradley Holland2. 1. Division of Urology, Department of Surgery, Southern Illinois University School of Medicine, Springfield, IL, U.S.A. salanee@siumed.edu. 2. Division of Urology, Department of Surgery, Southern Illinois University School of Medicine, Springfield, IL, U.S.A.
Abstract
AIM: We examined a national database to investigate the role of lymph node dissection (LND) in adrenocortical carcinoma (ACC) treated surgically. PATIENTS AND METHODS: Patient data diagnosed with ACC between 1991 and 2011 were extracted from a national database. Predictors of LND, positive lymph nodes on LND, and the association between positive LND and cancer-specific death were examined. RESULTS: Only 5.39% of patients underwent LND, and 31.03% had positive lymph nodes. Disease stage was the only significant predictor of LND (odds ratio=3.061; 95% confidence interval=1.158-8.091), and finding more than one positive lymph nodes on LND was the only significant predictor of cancer-specific death (hazard ratio=3.13; 95% confidence interval=1.233-7.95) in tumors larger than 3 cm in size. CONCLUSION: LND is not a common practice in treating ACC in the United States. The finding of more than one positive lymph nodes on LND for ACC is associated with poor prognosis. Copyright
AIM: We examined a national database to investigate the role of lymph node dissection (LND) in adrenocortical carcinoma (ACC) treated surgically. PATIENTS AND METHODS: Patient data diagnosed with ACC between 1991 and 2011 were extracted from a national database. Predictors of LND, positive lymph nodes on LND, and the association between positive LND and cancer-specific death were examined. RESULTS: Only 5.39% of patients underwent LND, and 31.03% had positive lymph nodes. Disease stage was the only significant predictor of LND (odds ratio=3.061; 95% confidence interval=1.158-8.091), and finding more than one positive lymph nodes on LND was the only significant predictor of cancer-specific death (hazard ratio=3.13; 95% confidence interval=1.233-7.95) in tumors larger than 3 cm in size. CONCLUSION: LND is not a common practice in treating ACC in the United States. The finding of more than one positive lymph nodes on LND for ACC is associated with poor prognosis. Copyright
Authors: Anne Hendricks; Sophie Müller; Martin Fassnacht; Christoph-Thomas Germer; Verena A Wiegering; Armin Wiegering; Joachim Reibetanz Journal: Cancers (Basel) Date: 2022-01-07 Impact factor: 6.575