Courtney Webre1, Nicole Shonka2, Lynette Smith3, Diane Liu4, John De Groot4. 1. Texas Agricultural and Mechanical College Health Science Center College of Medicine, Bryan, TX, U.S.A. 2. University of Nebraska Medical Center, Omaha, NE, U.S.A. nshonka@unmc.edu. 3. University of Nebraska Medical Center, Omaha, NE, U.S.A. 4. University of Texas - M.D. Anderson Cancer Center, Houston, TX, U.S.A.
Abstract
BACKGROUND: While procarbazine with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (PC) added to vincristine (PCV) was proven beneficial in the treatment of co-deleted anaplastic oligodendroglioma (AO), the question of whether PC alone is sufficient is important, as vincristine adds toxicity with uncertain benefit. This retrospective study provides a comparison of PC and PCV. PATIENTS AND METHODS: Patients diagnosed with AO treated at the M.D. Anderson Cancer Center from June 1, 1993 to October 13, 2009 were selected from the database and were eligible if diagnosed with a primary AO and treated with either PC or PCV at some point. Ninety-seven patients were treated with such chemotherapy before first progression. RESULTS: Initial treatment included radiation and chemotherapy (81.4%) or chemotherapy alone (18.6%). Twenty-one patients (21.6%) received PC during primary treatment, while 76 patients (78.4%) received PCV. Eleven patients reported neurotoxicity in the PCV arm vs. none in the PC arm. Out of the 97 patients, 45 were alive at last contact, with a median follow-up of 9.9 years. The median overall survival was 6.5 years (95% confidence interval=4.8-16.7 years), while the median progression-free survival was 2.9 years (95% confidence interval=2.0-6.3 years); these differences were not significant (p=0.61 and p=0.28, respectively). CONCLUSION: Initial therapy with PC achieved comparable results to those of PCV with a median follow-up of 9.9 years. Neurotoxicity was more frequent with vincristine. Although selecting only for patients with AO, rather than those with mixed histology, increased the likelihood of selecting for patients with tumors with co-deletions, further studies with correlative co-deletion status are required. Copyright
BACKGROUND: While procarbazine with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (PC) added to vincristine (PCV) was proven beneficial in the treatment of co-deleted anaplastic oligodendroglioma (AO), the question of whether PC alone is sufficient is important, as vincristine adds toxicity with uncertain benefit. This retrospective study provides a comparison of PC and PCV. PATIENTS AND METHODS: Patients diagnosed with AO treated at the M.D. Anderson Cancer Center from June 1, 1993 to October 13, 2009 were selected from the database and were eligible if diagnosed with a primary AO and treated with either PC or PCV at some point. Ninety-seven patients were treated with such chemotherapy before first progression. RESULTS: Initial treatment included radiation and chemotherapy (81.4%) or chemotherapy alone (18.6%). Twenty-one patients (21.6%) received PC during primary treatment, while 76 patients (78.4%) received PCV. Eleven patients reported neurotoxicity in the PCV arm vs. none in the PC arm. Out of the 97 patients, 45 were alive at last contact, with a median follow-up of 9.9 years. The median overall survival was 6.5 years (95% confidence interval=4.8-16.7 years), while the median progression-free survival was 2.9 years (95% confidence interval=2.0-6.3 years); these differences were not significant (p=0.61 and p=0.28, respectively). CONCLUSION: Initial therapy with PC achieved comparable results to those of PCV with a median follow-up of 9.9 years. Neurotoxicity was more frequent with vincristine. Although selecting only for patients with AO, rather than those with mixed histology, increased the likelihood of selecting for patients with tumors with co-deletions, further studies with correlative co-deletion status are required. Copyright
Authors: A Wick; A Sander; M Koch; M Bendszus; S Combs; T Haut; A Dormann; S Walter; M Pertz; J Merkle-Lock; N Selkrig; R Limprecht; L Baumann; M Kieser; F Sahm; U Schlegel; F Winkler; M Platten; W Wick; T Kessler Journal: BMC Cancer Date: 2022-06-13 Impact factor: 4.638
Authors: Stephen Ahn; Young Il Kim; Ja Young Shin; Jae-Sung Park; Changyoung Yoo; Youn Soo Lee; Yong-Kil Hong; Sin-Soo Jeun; Seung Ho Yang Journal: Oncol Lett Date: 2022-02-09 Impact factor: 2.967
Authors: Se-Hyuk Kim; Heon Yoo; Jong Hee Chang; Chae-Yong Kim; Dong Sup Chung; Se Hoon Kim; Sung-Hae Park; Youn Soo Lee; Seung Ho Yang Journal: J Korean Med Sci Date: 2018-05-10 Impact factor: 2.153