Marilia Oliveira Morais1, Marcela Ramos Abrahão Elias1, Cláudio Rodrigues Leles2, Juliana Castro Dourado Pinezi3, Elismauro Francisco Mendonça4,5. 1. Dental School, Federal University of Goiás, Goiânia, Brazil. 2. Department of Restorative Dentistry, Dental School, Federal University of Goiás, Goiânia, Brazil. 3. Radiotherapy Department of the Araújo Jorge Hospital, Association of Cancer Combat of Goiás, Goiânia, Brazil. 4. Department of Stomatology (Oral Pathology and Radiology), Dental School, Federal University of Goiás, Goiânia, Brazil. elismaur@ufg.br. 5. Disciplina de Patologia Geral e Bucal, Faculdade de Odontologia, Praça Universitária S/N Setor Universitário, CEP: 74605-220, Goiânia, Brazil. elismaur@ufg.br.
Abstract
PURPOSE: The purpose of this study was to assess patient adherence to an oral preventive measures (OPM) protocol and its impact on cancer treatment outcomes. METHODS: A retrospective cohort of oral cancer of 133 patients submitted to radiotherapy (RT) was selected, excluding those with metastasis. Patients were grouped according to their local tumor response after finishing RT (favorable or unfavorable) and adherence to an OPM (none, ≤6 months, and >6 months). OPM included education and counseling about adverse effects, elimination of infection foci, restorative procedures, fluoride therapy, oral rehydration, and maintenance and supervision of oral hygiene throughout treatment. Clinical and pathological characteristics were recorded, and patient outcomes (frequency of adverse effects, RT interruption, and overall survival) were analyzed. RESULTS: Patients with higher adherence to the OPM had greater occurrence of RT interruption as a consequence of symptoms (p = 0.01); however, these patients were more likely to complete the established RT protocol (p = 0.02). Overall survival (p = 0.01) was higher in the group with higher adherence. CONCLUSIONS: This study suggests that the implementation of oral preventive measures may contribute to improving the prognosis of squamous cell carcinoma (SCC) treatment by reducing the negative impact of oral complications.
PURPOSE: The purpose of this study was to assess patient adherence to an oral preventive measures (OPM) protocol and its impact on cancer treatment outcomes. METHODS: A retrospective cohort of oral cancer of 133 patients submitted to radiotherapy (RT) was selected, excluding those with metastasis. Patients were grouped according to their local tumor response after finishing RT (favorable or unfavorable) and adherence to an OPM (none, ≤6 months, and >6 months). OPM included education and counseling about adverse effects, elimination of infection foci, restorative procedures, fluoride therapy, oral rehydration, and maintenance and supervision of oral hygiene throughout treatment. Clinical and pathological characteristics were recorded, and patient outcomes (frequency of adverse effects, RT interruption, and overall survival) were analyzed. RESULTS:Patients with higher adherence to the OPM had greater occurrence of RT interruption as a consequence of symptoms (p = 0.01); however, these patients were more likely to complete the established RT protocol (p = 0.02). Overall survival (p = 0.01) was higher in the group with higher adherence. CONCLUSIONS: This study suggests that the implementation of oral preventive measures may contribute to improving the prognosis of squamous cell carcinoma (SCC) treatment by reducing the negative impact of oral complications.
Authors: Matthias Kreppel; Hans Theodor Eich; Alexander Kübler; Joachim E Zöller; Martin Scheer Journal: J Surg Oncol Date: 2010-10-01 Impact factor: 3.454
Authors: Rajesh V Lalla; Joanne Bowen; Andrei Barasch; Linda Elting; Joel Epstein; Dorothy M Keefe; Deborah B McGuire; Cesar Migliorati; Ourania Nicolatou-Galitis; Douglas E Peterson; Judith E Raber-Durlacher; Stephen T Sonis; Sharon Elad Journal: Cancer Date: 2014-02-25 Impact factor: 6.860
Authors: Rafaela Maia Almendra Mattos; Regina Maria Holanda de Mendonça; Simone Dos Santos Aguiar Journal: Support Care Cancer Date: 2019-05-23 Impact factor: 3.603
Authors: Catherine H L Hong; Luiz Alcino Gueiros; Janet S Fulton; Karis Kin Fong Cheng; Abhishek Kandwal; Dimitra Galiti; Jane M Fall-Dickson; Jorgen Johansen; Suzanne Ameringer; Tomoko Kataoka; Dianna Weikel; June Eilers; Vinasha Ranna; Anusha Vaddi; Rajesh V Lalla; Paolo Bossi; Sharon Elad Journal: Support Care Cancer Date: 2019-07-08 Impact factor: 3.603
Authors: Kristina Bertl; Philippe Savvidis; Edmund Benjamin Kukla; Steffen Schneider; Konstantin Zauza; Corinna Bruckmann; Andreas Stavropoulos Journal: Clin Oral Investig Date: 2021-11-18 Impact factor: 3.573