| Literature DB >> 26408183 |
Bin Chen1,2, Wenyan Pan3, Xiaoxi Lin4, Zhenzhen Hu5, Yunbo Jin4, Hui Chen4, Gang Ma4, Yajing Qiu4, Lei Chang4, Chen Hua4, Yun Zou4, Yang Gao4, Hanru Ying4, Dongze Lv4.
Abstract
Cutaneous squamous cell carcinoma (cSCC) is an epidermal keratinocyte-derived skin tumor, which is the second most common skin cancer in the general population. Recently, studies showed that microRNAs (miRNAs) played an important role in the development of cancer. In our study, we showed that the expression of SRCIN1 was lower in cSCC tissues than in the matched normal tissues. Moreover, there was significant inversed correlation between miR-346 and SRCIN1 in cSCC tissues. The luciferase reporter assay data showed that miR-346 can target the SRCIN1 message via the 3'-untranslated region (UTR) of SRCIN1. Overexpression of miR-346 inhibited the messenger RNA (mRNA) and protein expression of SRCIN1 in the A431 cells. In addition, ectopic expression of miR-346 promoted the A431 cell proliferation and migration. Meanwhile, SRCIN1 overexpression inhibited the A431 cell proliferation and migration. Rescue experiment has showed that SRCIN1 overexpression reduced the miR-346-induced A431 cell proliferation and migration. Herein, this study may provide miR-346 as a new therapeutic target for cSCC.Entities:
Keywords: Cutaneous squamous cell carcinoma; Oncogene; SRCIN1; miR-346
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Year: 2015 PMID： 26408183 DOI： 10.1007/s13277-015-4046-2
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283