Literature DB >> 2640776

Cardiovascular and respiratory effects of medetomidine in dogs and influence of anticholinergics.

O Vainio, L Palmu.   

Abstract

A total of 10 laboratory beagles was used to determine the cardiovascular and respiratory effects of medetomidine. The effects of atropine sulphate and glycopyrrolate on heart rate were also observed. Xylazine was included as a positive control. Medetomidine induced initial hypertension followed by a longer lasting hypotensive period. Evident bradycardia with second degree atrioventricular blocks and decrease in respiratory frequency was observed. Atropine sulphate and glycopyrrolate transiently abolished the bradycardic effect of medetomidine. Xylazine exhibited a similar cardiovascular and respiratory pattern to medetomidine.

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Year:  1989        PMID： 2640776      PMCID： PMC8142219     

Source DB:  PubMed          Journal:  Acta Vet Scand        ISSN： 0044-605X            Impact factor:   1.695


  15 in total

1.  SIMPLIFIED TECHNIQUE FOR CHRONIC CATHETERIZATION OF BLOOD VESSELS.

Authors:  J A HERD; A C BARGER
Journal:  J Appl Physiol       Date:  1964-07       Impact factor: 3.531

2.  Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist.

Authors:  R Virtanen; J M Savola; V Saano; L Nyman
Journal:  Eur J Pharmacol       Date:  1988-05-20       Impact factor: 4.432

3.  Cardiovascular and respiratory effects of xylazine in sheep.

Authors:  M A Aziz; S S Carlyle
Journal:  Zentralbl Veterinarmed A       Date:  1978-04

4.  Preliminary report on the cardiorespiratory effects of the antagonist to detomidine, MPV-1248.

Authors:  L Nilsfors; C Kvart
Journal:  Acta Vet Scand Suppl       Date:  1986

5.  Xylazine-induced depression and its antagonism by alpha adrenergic blocking agents.

Authors:  W H Hsu
Journal:  J Pharmacol Exp Ther       Date:  1981-07       Impact factor: 4.030

6.  Sedative and analgesic effects of medetomidine in dogs.

Authors:  O Vainio; T Vähä-Vahe; L Palmu
Journal:  J Vet Pharmacol Ther       Date:  1989-06       Impact factor: 1.786

7.  Effect of xylazine hydrochloride on canine splenic weight: an index of vascular capacity.

Authors:  J A Hubbell; W W Muir
Journal:  Am J Vet Res       Date:  1982-12       Impact factor: 1.156

8.  Evidence for medetomidine as a selective and potent agonist at alpha 2-adrenoreceptors.

Authors:  J M Savola; H Ruskoaho; J Puurunen; J S Salonen; N T Kärki
Journal:  J Auton Pharmacol       Date:  1986-12

9.  Hemodynamic effects of xylazine in the calf.

Authors:  K B Campbell; P A Klavano; P Richardson; J E Alexander
Journal:  Am J Vet Res       Date:  1979-12       Impact factor: 1.156

10.  Effect of xylazine on heart rate and arterial blood pressure in conscious dogs, as influenced by atropine, 4-aminopyridine, doxapram, and yohimbine.

Authors:  W H Hsu; Z X Lu; F B Hembrough
Journal:  J Am Vet Med Assoc       Date:  1985-01-15       Impact factor: 1.936
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  10 in total

Review 1.  Perioperative use of selective alpha-2 agonists and antagonists in small animals.

Authors:  Kip A Lemke
Journal:  Can Vet J       Date:  2004-06       Impact factor: 1.008

2.  Comparative cardiopulmonary effects of carfentanil-xylazine and medetomidine-ketamine used for immobilization of mule deer and mule deer/white-tailed deer hybrids.

Authors:  N A Caulkett; P H Cribb; J C Haigh
Journal:  Can J Vet Res       Date:  2000-01       Impact factor: 1.310

3.  Comparative responses to propofol anaesthesia alone and with alpha 2-adrenergic medications in a canine model.

Authors:  A Bufalari; C E Short; C Giannoni; O Vainio
Journal:  Acta Vet Scand       Date:  1996       Impact factor: 1.695

4.  Comparison of medetomidine and fentanyl-droperidol in dogs: sedation, analgesia, arterial blood gases and lactate levels.

Authors:  G R Pettifer; D H Dyson
Journal:  Can J Vet Res       Date:  1993-04       Impact factor: 1.310

5.  Survey of utilization of medetomidine and atipamezole in private veterinary practice in Quebec in 2002.

Authors:  M Johanna Kaartinen; Sophie Cuvelliez; Line Brouillard; Yves Rondenay; Jean Jacques Kona-Boun; Eric Troncy
Journal:  Can Vet J       Date:  2007-07       Impact factor: 1.008

Review 6.  A review of the physiological effects of alpha2-agonists related to the clinical use of medetomidine in small animal practice.

Authors:  Melissa D Sinclair
Journal:  Can Vet J       Date:  2003-11       Impact factor: 1.008

7.  An evaluation of the influence of medetomidine hydrochloride and atipamezole hydrochloride on the arrhythmogenic dose of epinephrine in dogs during halothane anesthesia.

Authors:  G R Pettifer; D H Dyson; W N McDonell
Journal:  Can J Vet Res       Date:  1996-01       Impact factor: 1.310

8.  Comparison of the effects of three different combinations of general anesthetics on the electroretinogram of dogs.

Authors:  Man Bok Jeong; Kristina Narfström; Shin Ae Park; Je Min Chae; Kang Moon Seo
Journal:  Doc Ophthalmol       Date:  2009-04-14       Impact factor: 2.379

9.  Medetomidine- and medetomidine-ketamine-induced immobilization in blue foxes (Alopex lagopus) and its reversal by atipamezole.

Authors:  H H Jalanka
Journal:  Acta Vet Scand       Date:  1990       Impact factor: 1.695

10.  A Double-Blinded, Randomized Comparison of Medetomidine-Tiletamine-Zolazepam and Dexmedetomidine-Tiletamine-Zolazepam Anesthesia in Free-Ranging Brown Bears (Ursus Arctos).

Authors:  Núria Fandos Esteruelas; Marc Cattet; Andreas Zedrosser; Gordon B Stenhouse; Susanne Küker; Alina L Evans; Jon M Arnemo
Journal:  PLoS One       Date:  2017-01-24       Impact factor: 3.240
  10 in total

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