| Literature DB >> 26407231 |
Zhen Liang1, Zhihua Ren1, Shuang Gao1, Yun Chen1, Yanyi Yang1, Dan Yang1, Junliang Deng2, Zhicai Zuo1, Ya Wang1, Liuhong Shen1.
Abstract
This study was performed to investigate the individual and combined toxic effects of deoxynivalenol (DON) and zearalenone (ZEA) on mouse kidney. A total of 360 female mice were divided into nine groups. Each group received intraperitoneal injection of solvent (control), DON, ZEA, or DON+ZEA four times for 12d. Results showed that ZEA and/or DON increased the apoptosis rate in the kidney, as well as the levels of serum creatinine and blood urea nitrogen. DON and/or ZEA also induced renal oxidative stress as indicated by increased malondialdehyde concentration and nitric oxide level and reduced superoxide dismutase enzyme activity and hydroxyl radical inhibiting capacity. The observed changes were dose and time dependent. This study reports that DON and/or ZEA induced apoptosis, dysfunction, and oxidative stress in mouse kidney. Furthermore, the combination of DON+ZEA exhibited a sub-additive nephrotoxic effect.Entities:
Keywords: Deoxynivalenol; Kidney; Oxidative stress; Zearalenone
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Year: 2015 PMID： 26407231 DOI： 10.1016/j.etap.2015.08.029
Source DB: PubMed Journal: Environ Toxicol Pharmacol ISSN： 1382-6689 Impact factor: 4.860