| Literature DB >> 26406363 |
Jeffrey L Brodsky1, Raymond A Frizzell2.
Abstract
The most prevalent form of cystic fibrosis arises from an amino acid deletion in the cystic fibrosis transmembrane conductance regulator, CFTR. A recently approved treatment for individuals homozygous for this mutation combines a chemical corrector, which helps CFTR fold, and a potentiator that increases CFTR channel activity.Entities:
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Year: 2015 PMID： 26406363 PMCID： PMC4865247 DOI： 10.1016/j.cell.2015.09.003
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582