Literature DB >> 26405611

"Messieurs, c'est les microbes qui auront le dernier mot": Gentlemen, it is the microbes who have the last word (Louis Pasteur)-Fusobacterium nucleatum protect tumors from killing by immune cells.

Chamutal Gur1, Ofer Mandelboim2, Gilad Bachrach3.   

Abstract

Fusobacterium nucleatum is present in colon cancers where it was shown to generate a proinflammatory microenvironment that supports colorectal neoplasia progression. Remarkably, alongside with proinflammatory stimulation, fusobacteria also inhibit cytotoxicity of immune cells. Thus, it appears as if tumors exploit fusobacteria to generate a favorable proinflammatory and anti-cytotoxic microenvironment.

Entities:  

Keywords:  NK cells; colon adenocarcinoma; fusobacteria; tumor immunity

Year:  2015        PMID： 26405611      PMCID： PMC4570130          DOI： 10.1080/2162402X.2015.1038690

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT'S LYMPHOMA.

Authors:  M A EPSTEIN; B G ACHONG; Y M BARR
Journal:  Lancet       Date:  1964-03-28       Impact factor: 79.321

Review 2.  A bacterial driver-passenger model for colorectal cancer: beyond the usual suspects.

Authors:  Harold Tjalsma; Annemarie Boleij; Julian R Marchesi; Bas E Dutilh
Journal:  Nat Rev Microbiol       Date:  2012-06-25       Impact factor: 60.633

3.  Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin.

Authors:  Mara Roxana Rubinstein; Xiaowei Wang; Wendy Liu; Yujun Hao; Guifang Cai; Yiping W Han
Journal:  Cell Host Microbe       Date:  2013-08-14       Impact factor: 21.023

4.  Fusobacterium nucleatum apoptosis-inducing outer membrane protein.

Authors:  C W Kaplan; R Lux; T Huynh; A Jewett; W Shi; S Kinder Haake
Journal:  J Dent Res       Date:  2005-08       Impact factor: 6.116

5.  Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment.

Authors:  Aleksandar D Kostic; Eunyoung Chun; Lauren Robertson; Jonathan N Glickman; Carey Ann Gallini; Monia Michaud; Thomas E Clancy; Daniel C Chung; Paul Lochhead; Georgina L Hold; Emad M El-Omar; Dean Brenner; Charles S Fuchs; Matthew Meyerson; Wendy S Garrett
Journal:  Cell Host Microbe       Date:  2013-08-14       Impact factor: 21.023

6.  The search for infectious causes of human cancers: where and why (Nobel lecture).

Authors:  Harald zur Hausen
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

7.  Natural killer cell-mediated host defense against uropathogenic E. coli is counteracted by bacterial hemolysinA-dependent killing of NK cells.

Authors:  Chamutal Gur; Shunit Coppenhagen-Glazer; Shilo Rosenberg; Rachel Yamin; Jonatan Enk; Ariella Glasner; Yotam Bar-On; Omer Fleissig; Ronit Naor; Jawad Abed; Dror Mevorach; Zvi Granot; Gilad Bachrach; Ofer Mandelboim
Journal:  Cell Host Microbe       Date:  2013-12-11       Impact factor: 21.023

8.  Direct recognition of Fusobacterium nucleatum by the NK cell natural cytotoxicity receptor NKp46 aggravates periodontal disease.

Authors:  Stella Chaushu; Asaf Wilensky; Chamutal Gur; Lior Shapira; Moran Elboim; Gili Halftek; David Polak; Hagit Achdout; Gilad Bachrach; Ofer Mandelboim
Journal:  PLoS Pathog       Date:  2012-03-22       Impact factor: 6.823

9.  A SARCOMA OF THE FOWL TRANSMISSIBLE BY AN AGENT SEPARABLE FROM THE TUMOR CELLS.

Authors:  P Rous
Journal:  J Exp Med       Date:  1911-04-01       Impact factor: 14.307

10.  Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack.

Authors:  Chamutal Gur; Yara Ibrahim; Batya Isaacson; Rachel Yamin; Jawad Abed; Moriya Gamliel; Jonatan Enk; Yotam Bar-On; Noah Stanietsky-Kaynan; Shunit Coppenhagen-Glazer; Noam Shussman; Gideon Almogy; Angelica Cuapio; Erhard Hofer; Dror Mevorach; Adi Tabib; Rona Ortenberg; Gal Markel; Karmela Miklić; Stipan Jonjic; Caitlin A Brennan; Wendy S Garrett; Gilad Bachrach; Ofer Mandelboim
Journal:  Immunity       Date:  2015-02-10       Impact factor: 31.745
  10 in total
  3 in total

1.  Tumor Targeting by Fusobacterium nucleatum: A Pilot Study and Future Perspectives.

Authors:  Jawad Abed; Naseem Maalouf; Lishay Parhi; Stella Chaushu; Ofer Mandelboim; Gilad Bachrach
Journal:  Front Cell Infect Microbiol       Date:  2017-06-30       Impact factor: 5.293

2.  Colonic Mucosal Microbiota in Colorectal Cancer: A Single-Center Metagenomic Study in Saudi Arabia.

Authors:  Ahmed O Alomair; Ibrahim Masoodi; Essam J Alyamani; Abed A Allehibi; Adel N Qutub; Khalid N Alsayari; Musaad A Altammami; Ali S Alshanqeeti
Journal:  Gastroenterol Res Pract       Date:  2018-05-16       Impact factor: 2.260

3.  Sturgeon Chondroitin Sulfate Restores the Balance of Gut Microbiota in Colorectal Cancer Bearing Mice.

Authors:  Ruiyun Wu; Qian Shen; Pinglan Li; Nan Shang
Journal:  Int J Mol Sci       Date:  2022-03-28       Impact factor: 6.208
  3 in total

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