Literature DB >> 26405605

Perforin-dependent cytotoxicity: 'Kiss of death' or prolonged embrace with darker elocation-idnseque11es?

Joseph A Trapani1, Ilia Voskoboinik1, Misty R Jenkins1.   

Abstract

Failure of natural killer (NK) cells or cytotoxic T-lymphocytes (CTL) to kill cognate target cells results in cytokine/chemokine hypersecretion and markedly delayed killer/target cell detachment. With congenital perforin deficiency, fatal cytokine storm results. In cancer cells, where corrupted apoptotic signaling frequently delays apoptosis, we propose that failed death may alter the tumor microenvironment and skew immune infiltrates, even when perforin is delivered normally.

Entities:  

Keywords:  FHL; apoptosis; detachment; granzyme; immunotherapy; inflammation; perforin

Year:  2015        PMID： 26405605      PMCID： PMC4570094          DOI： 10.1080/2162402X.2015.1036215

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

Review 1.  Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death.

Authors:  Jamie A Lopez; Amelia J Brennan; James C Whisstock; Ilia Voskoboinik; Joseph A Trapani
Journal:  Trends Immunol       Date:  2012-05-18       Impact factor: 16.687

2.  The major human and mouse granzymes are structurally and functionally divergent.

Authors:  Dion Kaiserman; Catherina H Bird; Jiuru Sun; Antony Matthews; Kheng Ung; James C Whisstock; Philip E Thompson; Joseph A Trapani; Phillip I Bird
Journal:  J Cell Biol       Date:  2006-11-20       Impact factor: 10.539

3.  Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse.

Authors:  Jamie A Lopez; Misty R Jenkins; Jesse A Rudd-Schmidt; Amelia J Brennan; Jillian C Danne; Stuart I Mannering; Joseph A Trapani; Ilia Voskoboinik
Journal:  J Immunol       Date:  2013-07-24       Impact factor: 5.422

4.  Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack.

Authors:  Jamie A Lopez; Olivia Susanto; Misty R Jenkins; Natalya Lukoyanova; Vivien R Sutton; Ruby H P Law; Angus Johnston; Catherina H Bird; Phillip I Bird; James C Whisstock; Joseph A Trapani; Helen R Saibil; Ilia Voskoboinik
Journal:  Blood       Date:  2013-02-01       Impact factor: 22.113

Review 5.  Familial and acquired hemophagocytic lymphohistiocytosis.

Authors:  G E Janka
Journal:  Annu Rev Med       Date:  2012       Impact factor: 13.739

6.  Graft reaction in tissue culture by normal rat lymphocytes.

Authors:  H Ginsburg; W Ax; G Berke
Journal:  Transplant Proc       Date:  1969-03       Impact factor: 1.066

7.  Perforin gene defects in familial hemophagocytic lymphohistiocytosis.

Authors:  S E Stepp; R Dufourcq-Lagelouse; F Le Deist; S Bhawan; S Certain; P A Mathew; J I Henter; M Bennett; A Fischer; G de Saint Basile; V Kumar
Journal:  Science       Date:  1999-12-03       Impact factor: 47.728

Review 8.  Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.

Authors:  Geneviève de Saint Basile; Gaël Ménasché; Alain Fischer
Journal:  Nat Rev Immunol       Date:  2010-07-16       Impact factor: 53.106

9.  A natural genetic variant of granzyme B confers lethality to a common viral infection.

Authors:  Christopher E Andoniou; Vivien R Sutton; Matthew E Wikstrom; Peter Fleming; Kevin Y T Thia; Antony Y Matthews; Dion Kaiserman; Iona S Schuster; Jerome D Coudert; Preethi Eldi; Geeta Chaudhri; Gunasegaran Karupiah; Phillip I Bird; Joseph A Trapani; Mariapia A Degli-Esposti
Journal:  PLoS Pathog       Date:  2014-12-11       Impact factor: 6.823

10.  Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time.

Authors:  Misty R Jenkins; Jesse A Rudd-Schmidt; Jamie A Lopez; Kelly M Ramsbottom; Stuart I Mannering; Daniel M Andrews; Ilia Voskoboinik; Joseph A Trapani
Journal:  J Exp Med       Date:  2015-03-02       Impact factor: 14.307
  10 in total
  1 in total

Review 1.  Natural Killer Cells in Systemic Autoinflammatory Diseases: A Focus on Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome.

Authors:  Jessica Vandenhaute; Carine H Wouters; Patrick Matthys
Journal:  Front Immunol       Date:  2020-01-15       Impact factor: 7.561
  1 in total

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