Literature DB >> 26405594

HIF-1 is a critical target of pancreatic cancer.

Jihui Hao1.   

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal digestive tract malignancies. Hypoxia-inducible factor (HIF-1) is over-expressed in pancreatic cancer and associated with poor prognosis. During the past several years, we focused on identifying the function of HIF-1 and the antitumor effect of HIF-1 inhibitors on PDAC, especially in regards to immunogenic cell death.

Entities:  

Year:  2015        PMID： 26405594      PMCID： PMC4570099          DOI： 10.1080/2162402X.2015.1026535

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

1.  Polymorphisms in the hypoxia-inducible factor-1α gene confer susceptibility to pancreatic cancer.

Authors:  Xiuchao Wang; Yingwei Liu; He Ren; Zhanna Yuan; Shasha Li; Jun Sheng; Tiansuo Zhao; Yong Chen; Fenghua Liu; Feng Wang; He Huang; Jihui Hao
Journal:  Cancer Biol Ther       Date:  2011-09-01       Impact factor: 4.742

2.  LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer.

Authors:  Tiansuo Zhao; He Ren; Jing Li; Jing Chen; Huan Zhang; Wen Xin; Yan Sun; Lei Sun; Yongwei Yang; Junwei Sun; Xiuchao Wang; Song Gao; Chongbiao Huang; Huafeng Zhang; Shengyu Yang; Jihui Hao
Journal:  Cancer Res       Date:  2014-11-10       Impact factor: 12.701

3.  Hypoxia inducible factor (HIF)-1α directly activates leptin receptor (Ob-R) in pancreatic cancer cells.

Authors:  He Ren; Lingling Jia; Tiansuo Zhao; Huan Zhang; Jing Chen; Shaoguang Yang; Jingcheng Liu; Ming Yu; Jihui Hao
Journal:  Cancer Lett       Date:  2014-08-15       Impact factor: 8.679

4.  The CX3CL1/CX3CR1 reprograms glucose metabolism through HIF-1 pathway in pancreatic adenocarcinoma.

Authors:  He Ren; Tiansuo Zhao; Junwei Sun; Xiuchao Wang; Jingcheng Liu; Song Gao; Ming Yu; Jihui Hao
Journal:  J Cell Biochem       Date:  2013-11       Impact factor: 4.429

5.  Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha.

Authors:  Mei Y Koh; Taly Spivak-Kroizman; Sara Venturini; Sarah Welsh; Ryan R Williams; D Lynn Kirkpatrick; Garth Powis
Journal:  Mol Cancer Ther       Date:  2008-01       Impact factor: 6.261

6.  Differential effects of leptin on cancer in vitro.

Authors:  Ponnandai Somasundar; Alice K Yu; Linda Vona-Davis; David W McFadden
Journal:  J Surg Res       Date:  2003-07       Impact factor: 2.192

7.  Hypoxia-inducible factor-1 promotes pancreatic ductal adenocarcinoma invasion and metastasis by activating transcription of the actin-bundling protein fascin.

Authors:  Xiao Zhao; Song Gao; He Ren; Wei Sun; Huan Zhang; Jianwei Sun; Shengyu Yang; Jihui Hao
Journal:  Cancer Res       Date:  2014-03-05       Impact factor: 12.701

8.  Immunogenic cell death inducers as anticancer agents.

Authors:  Oliver Kepp; Laura Senovilla; Guido Kroemer
Journal:  Oncotarget       Date:  2014-07-30

9.  Hypoxia-inducible factor-1α regulates chemotactic migration of pancreatic ductal adenocarcinoma cells through directly transactivating the CX3CR1 gene.

Authors:  Tiansuo Zhao; Song Gao; Xiuchao Wang; Jingcheng Liu; Yitao Duan; Zhanna Yuan; Jun Sheng; Shasha Li; Feng Wang; Ming Yu; He Ren; Jihui Hao
Journal:  PLoS One       Date:  2012-08-27       Impact factor: 3.240

10.  CypA, a gene downstream of HIF-1α, promotes the development of PDAC.

Authors:  Huan Zhang; Jing Chen; Fenghua Liu; Chuntao Gao; Xiuchao Wang; Tiansuo Zhao; Jingcheng Liu; Song Gao; Xiao Zhao; He Ren; Jihui Hao
Journal:  PLoS One       Date:  2014-03-24       Impact factor: 3.240
  10 in total
  8 in total

1.  Understanding the Mechanism of Cell Death in Gemcitabine Resistant Pancreatic Ductal Adenocarcinoma: A Systems Biology Approach.

Authors:  Imlimaong Aier; Pritish K Varadwaj
Journal:  Curr Genomics       Date:  2019-11       Impact factor: 2.236

2.  Hypoxia-induced lncRNA-NUTF2P3-001 contributes to tumorigenesis of pancreatic cancer by derepressing the miR-3923/KRAS pathway.

Authors:  Xiang Li; Shi-jiang Deng; Shuai Zhu; Yan Jin; Shi-peng Cui; Jing-yuan Chen; Cheng Xiang; Qun-ying Li; Chi He; Shu-feng Zhao; Heng-yu Chen; Yi Niu; Yang Liu; Shi-chang Deng; Chun-you Wang; Gang Zhao
Journal:  Oncotarget       Date:  2016-02-02

3.  Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes.

Authors:  Xiuchao Wang; He Ren; Tiansuo Zhao; Weidong Ma; Jie Dong; Shengjie Zhang; Wen Xin; Shengyu Yang; Li Jia; Jihui Hao
Journal:  Oncotarget       Date:  2016-03-22

4.  Natural Compound Methyl Protodioscin Suppresses Proliferation and Inhibits Glycolysis in Pancreatic Cancer.

Authors:  LianYu Chen; Chien-Shan Cheng; HuiFeng Gao; Ling Zhan; FengJiao Wang; Chao Qu; Ye Li; Peng Wang; Hao Chen; ZhiQiang Meng; LuMing Liu; HaiFeng Chen; Zhen Chen
Journal:  Evid Based Complement Alternat Med       Date:  2018-03-15       Impact factor: 2.629

5.  Reversine, a selective MPS1 inhibitor, induced autophagic cell death via diminished glucose uptake and ATP production in cholangiocarcinoma cells.

Authors:  Piya Prajumwongs; Orawan Waenphimai; Kulthida Vaeteewoottacharn; Sopit Wongkham; Kanlayanee Sawanyawisuth
Journal:  PeerJ       Date:  2021-01-07       Impact factor: 2.984

6.  Development and validation of a hypoxia-stemness-based prognostic signature in pancreatic adenocarcinoma.

Authors:  Xiong Tian; Jing Zheng; Wanlan Mou; Guoguang Lu; Shuaishuai Chen; Juping Du; Yufen Zheng; Shiyong Chen; Bo Shen; Jun Li; Na Wang
Journal:  Front Pharmacol       Date:  2022-07-21       Impact factor: 5.988

7.  Mechanistic Evaluation and Translational Signature of Gemcitabine-induced Chemoresistance by Quantitative Phosphoproteomics Analysis with iTRAQ Labeling Mass Spectrometry.

Authors:  Qingke Duan; Hengqiang Zhao; Zhengle Zhang; Hehe Li; Heshui Wu; Qiang Shen; Chunyou Wang; Tao Yin
Journal:  Sci Rep       Date:  2017-10-10       Impact factor: 4.379

Review 8.  The role of hypoxia-inducible factors in tumor angiogenesis and cell metabolism.

Authors:  Xiu Lv; Jincheng Li; Chuhong Zhang; Tian Hu; Sai Li; Sha He; Hanxing Yan; Yixi Tan; Mingsheng Lei; Meiling Wen; Jianhong Zuo
Journal:  Genes Dis       Date:  2016-12-14
  8 in total

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