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Literature DB >> 26405580

Fbxw7 suppresses cancer metastasis by inhibiting niche formation.

Abstract

Fbxw7 has been identified as an oncosuppressor protein in many types of cancer. We have recently shown that loss of Fbxw7 in bone marrow-derived stromal cells (BMSCs) promotes cancer metastasis by increasing production of the chemokine CCL2, which attracts monocytic myeloid-derived suppressor cells (Mo-MDSCs) and macrophages to the metastatic niche.

Entities: Disease Gene

Keywords: F-box protein; chemokine; metastasis; niche; ubiquitin ligase

Year: 2015 PMID： 26405580 PMCID： PMC4570111 DOI： 10.1080/2162402X.2015.1022308

Source DB: PubMed Journal: Oncoimmunology ISSN： 2162-4011 Impact factor: 8.110

8 in total

1. Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor.

Authors: N Gupta-Rossi; O Le Bail; H Gonen; C Brou; F Logeat; E Six; A Ciechanover; A Israël
Journal: J Biol Chem Date: 2001-06-25 Impact factor: 5.157

2. An anti-inflammatory drug, propagermanium, may target GPI-anchored proteins associated with an MCP-1 receptor, CCR2.

Authors: S Yokochi; H Hashimoto; Y Ishiwata; H Shimokawa; M Haino; Y Terashima; K Matsushima
Journal: J Interferon Cytokine Res Date: 2001-06 Impact factor: 2.607

Review 3. Microenvironmental regulation of tumor progression and metastasis.

Authors: Daniela F Quail; Johanna A Joyce
Journal: Nat Med Date: 2013-11 Impact factor: 53.440

Review 4. Tumor suppression by the Fbw7 ubiquitin ligase: mechanisms and opportunities.

Authors: Ryan J Davis; Markus Welcker; Bruce E Clurman
Journal: Cancer Cell Date: 2014-10-13 Impact factor: 31.743

5. The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog.

Authors: C Oberg; J Li; A Pauley; E Wolf; M Gurney; U Lendahl
Journal: J Biol Chem Date: 2001-07-18 Impact factor: 5.157

6. CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFα.

Authors: Guangwen Ren; Xin Zhao; Ying Wang; Xin Zhang; Xiaodong Chen; Chunliang Xu; Zeng-rong Yuan; Arthur I Roberts; Liying Zhang; Betty Zheng; Ting Wen; Yanyan Han; Arnold B Rabson; Jay A Tischfield; Changshun Shao; Yufang Shi
Journal: Cell Stem Cell Date: 2012-11-15 Impact factor: 24.633

Review 7. Inflammatory chemokines and metastasis--tracing the accessory.

Authors: L Borsig; M J Wolf; M Roblek; A Lorentzen; M Heikenwalder
Journal: Oncogene Date: 2013-07-15 Impact factor: 9.867

8. F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner.

Authors: Kanae Yumimoto; Sayuri Akiyoshi; Hiroki Ueo; Yasuaki Sagara; Ichiro Onoyama; Hiroaki Ueo; Shinji Ohno; Masaki Mori; Koshi Mimori; Keiichi I Nakayama
Journal: J Clin Invest Date: 2015-01-02 Impact factor: 14.808

8 in total

4 in total

Review 1. Trial Watch: Immunotherapy plus radiation therapy for oncological indications.

Authors: Erika Vacchelli; Norma Bloy; Fernando Aranda; Aitziber Buqué; Isabelle Cremer; Sandra Demaria; Alexander Eggermont; Silvia Chiara Formenti; Wolf Hervé Fridman; Jitka Fucikova; Jérôme Galon; Radek Spisek; Eric Tartour; Laurence Zitvogel; Guido Kroemer; Lorenzo Galluzzi
Journal: Oncoimmunology Date: 2016-07-25 Impact factor: 8.110