Literature DB >> 26405312

Fosaprepitant for the Treatment of Refractory Postoperative Nausea and Vomiting.

Linh H Tran1, Magdalena Cudny1, Dat Ngo1, Samit Patel1, Manuel Y Lam2.   

Abstract

Postoperative nausea and vomiting (PONV) is a debilitating condition that occurs in approximately 30% of patients undergoing general anesthesia. Premedication with 5-HT3 receptor antagonists and glucocorticoids is effective in clinical practice; however, 10% to 20% of patients still develop PONV. Currently, little is known about the treatment of refractory PONV. We present a case that illustrates the use of fosaprepitant for the treatment of refractory postoperative nausea and vomiting.

Entities:  

Keywords:  Emend; breakthrough; fosaprepitant; nausea; postoperative; refractory; vomiting

Year:  2015        PMID： 26405312      PMCID： PMC4567192          DOI： 10.1310/hpj5003-221

Source DB:  PubMed          Journal:  Hosp Pharm        ISSN： 0018-5787


  8 in total

1.  Aprepitant vs. multimodal prophylaxis in the prevention of nausea and vomiting following extended-release epidural morphine.

Authors:  Craig T Hartrick; Yeong-Shiuh Tang; David Hunstad; John Pappas; Kathy Muir; Cecile Pestano; Daniel Silvasi
Journal:  Pain Pract       Date:  2010-03-02       Impact factor: 3.183

2.  Neurokinin-1 receptor antagonism, aprepitant, effectively diminishes post-operative nausea and vomiting while increasing analgesic tolerance in laparoscopic gynecological procedures.

Authors:  Nami Kakuta; Yasuo M Tsutsumi; Yousuke T Horikawa; Hiroaki Kawano; Michiko Kinoshita; Katsuya Tanaka; Shuzo Oshita
Journal:  J Med Invest       Date:  2011-08

3.  Efficacy of repeat intravenous dosing of ondansetron in controlling postoperative nausea and vomiting: a randomized, double-blind, placebo-controlled multicenter trial.

Authors:  A L Kovac; T A O'Connor; M H Pearman; L J Kekoler; D Edmondson; V L Baughman; J J Angel; C Campbell; H G Jense; M Mingus; M B Shahvari; M R Creed
Journal:  J Clin Anesth       Date:  1999-09       Impact factor: 9.452

Review 4.  Risk factors for postoperative nausea and vomiting.

Authors:  Tong J Gan
Journal:  Anesth Analg       Date:  2006-06       Impact factor: 5.108

Review 5.  Management of postoperative nausea and vomiting: how to deal with refractory PONV.

Authors:  Johanna Jokinen; Andrew F Smith; Norbert Roewer; Leopold H J Eberhart; Peter Kranke
Journal:  Anesthesiol Clin       Date:  2012-08-14

6.  Preventing postoperative nausea and vomiting: post hoc analysis of pooled data from two randomized active-controlled trials of aprepitant.

Authors:  Pierre Diemunsch; Christian Apfel; Tong J Gan; Keith Candiotti; Beverly K Philip; Jacques Chelly; Alexandra D Carides; Judith K Evans; Tony W Ho; Theodore Reiss
Journal:  Curr Med Res Opin       Date:  2007-10       Impact factor: 2.580

7.  Systematic review on the recurrence of postoperative nausea and vomiting after a first episode in the recovery room - implications for the treatment of PONV and related clinical trials.

Authors:  Leopold H J Eberhart; Silke Frank; Henning Lange; Astrid M Morin; André Scherag; Hinnerk Wulf; Peter Kranke
Journal:  BMC Anesthesiol       Date:  2006-12-13       Impact factor: 2.217

8.  Aprepitant versus ondansetron in preoperative triple-therapy treatment of nausea and vomiting in neurosurgery patients: study protocol for a randomized controlled trial.

Authors:  Sergio Bergese; Adolfo Viloria; Alberto Uribe; Alejandra Antor; Soledad Fernandez
Journal:  Trials       Date:  2012-08-03       Impact factor: 2.279
  8 in total
  1 in total

1.  Fosaprepitant versus droperidol for prevention of PONV in craniotomy: a randomized double-blind study.

Authors:  Jun Atsuta; Satoki Inoue; Yuu Tanaka; Keiko Abe; Hiroyuki Nakase; Masahiko Kawaguchi
Journal:  J Anesth       Date:  2016-10-18       Impact factor: 2.078
  1 in total

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