Literature DB >> 26405057

Synthesis and base pairing studies of geranylated 2-thiothymidine, a natural variant of thymidine.

Rui Wang1, Srivathsan V Ranganathan2, Maria Basanta-Sanchez2, Fusheng Shen1, Alan Chen1, Jia Sheng1.   

Abstract

The synthesis and base pairing of DNA duplexes containing the geranylated 2-thiothymidine have been investigated. This naturally existing hydrophobic modification could grant better base pairing stability to the T-G pair over normal T-A and other mismatched pairs in the duplex context. This study provides a potential explanation for the different codon recognition preferences of the geranylated tRNAs.

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Year:  2015        PMID： 26405057     DOI： 10.1039/c5cc07479g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

1.  C5-substituents of uridines and 2-thiouridines present at the wobble position of tRNA determine the formation of their keto-enol or zwitterionic forms - a factor important for accuracy of reading of guanosine at the 3΄-end of the mRNA codons.

Authors:  Elzbieta Sochacka; Elzbieta Lodyga-Chruscinska; Justyna Pawlak; Marek Cypryk; Paulina Bartos; Katarzyna Ebenryter-Olbinska; Grazyna Leszczynska; Barbara Nawrot
Journal:  Nucleic Acids Res       Date:  2017-05-05       Impact factor: 16.971

2.  Oxidative opening of the aromatic ring: Tracing the natural history of a large superfamily of dioxygenase domains and their relatives.

Authors:  A Maxwell Burroughs; Margaret E Glasner; Kevin P Barry; Erika A Taylor; L Aravind
Journal:  J Biol Chem       Date:  2019-05-15       Impact factor: 5.157

3.  Transfer RNA Bound to MnmH Protein Is Enriched with Geranylated tRNA--A Possible Intermediate in Its Selenation?

Authors:  Gunilla Jäger; Peng Chen; Glenn R Björk
Journal:  PLoS One       Date:  2016-04-13       Impact factor: 3.240

Review 4.  The chemical diversity of RNA modifications.

Authors:  R Jordan Ontiveros; Julian Stoute; Kathy Fange Liu
Journal:  Biochem J       Date:  2019-04-26       Impact factor: 3.766

5.  Synthesis, base pairing and structure studies of geranylated RNA.

Authors:  Rui Wang; Sweta Vangaveti; Srivathsan V Ranganathan; Maria Basanta-Sanchez; Phensinee Haruehanroengra; Alan Chen; Jia Sheng
Journal:  Nucleic Acids Res       Date:  2016-06-15       Impact factor: 16.971

Review 6.  Chemical and Conformational Diversity of Modified Nucleosides Affects tRNA Structure and Function.

Authors:  Ville Y P Väre; Emily R Eruysal; Amithi Narendran; Kathryn L Sarachan; Paul F Agris
Journal:  Biomolecules       Date:  2017-03-16

7.  Terpene Chain Length Affects the Base Pairing Discrimination of S-geranyl-2-thiouridine in RNA Duplex.

Authors:  Phensinee Haruehanroengra; Sweta Vangaveti; Srivathsan V Ranganathan; Song Mao; Max Daniel Su; Alan A Chen; Jia Sheng
Journal:  iScience       Date:  2020-11-26

8.  S-Geranyl-2-thiouridine wobble nucleosides of bacterial tRNAs; chemical and enzymatic synthesis of S-geranylated-RNAs and their physicochemical characterization.

Authors:  Malgorzata Sierant; Grazyna Leszczynska; Klaudia Sadowska; Agnieszka Dziergowska; Michal Rozanski; Elzbieta Sochacka; Barbara Nawrot
Journal:  Nucleic Acids Res       Date:  2016-08-26       Impact factor: 16.971
  8 in total

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