Q Huang1, W Lai1, C Yuan2, S Shen3, D Cui1, J Zhao1, J Lin1, H Ren1, M Yang4. 1. Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China. 2. Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China. 3. School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China. 4. Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China minyanggz@yahoo.com.
Abstract
OBJECTIVE: To determine factors that may predict intestinal pseudo-obstruction (IpsO) in systemic lupus erythematosus (SLE) patients complicated by digestive manifestations. METHODS: SLE patients with digestive manifestations (n = 135) were followed at Southern Medical University affiliated Nanfang Hospital from 2000 until 2013. Demographic variables, clinical features, and laboratory data were compared between the two groups. Univariate and multivariate logistic regression models were used to establish factors that predispose to IpsO in these patients. RESULTS: At the end of the study period, 32 (23.7%) patients had developed IpsO. Mortality (9 patients) was infrequent and the cause of death was unrelated to IpsO. Independent predictors of IpsO in SLE were ureterectasia, anti-U1 RNP(+), peritonitis, and low C3 levels. CONCLUSIONS: Regular abdominal X-ray examinations are recommended in SLE patients with ureterectasia, anti-U1 RNP(+), peritonitis, or low C3 levels, as early diagnosis and therapy may prevent unnecessary surgical intervention and improve the disease course.
OBJECTIVE: To determine factors that may predict intestinal pseudo-obstruction (IpsO) in systemic lupus erythematosus (SLE) patients complicated by digestive manifestations. METHODS:SLEpatients with digestive manifestations (n = 135) were followed at Southern Medical University affiliated Nanfang Hospital from 2000 until 2013. Demographic variables, clinical features, and laboratory data were compared between the two groups. Univariate and multivariate logistic regression models were used to establish factors that predispose to IpsO in these patients. RESULTS: At the end of the study period, 32 (23.7%) patients had developed IpsO. Mortality (9 patients) was infrequent and the cause of death was unrelated to IpsO. Independent predictors of IpsO in SLE were ureterectasia, anti-U1 RNP(+), peritonitis, and low C3 levels. CONCLUSIONS: Regular abdominal X-ray examinations are recommended in SLEpatients with ureterectasia, anti-U1 RNP(+), peritonitis, or low C3 levels, as early diagnosis and therapy may prevent unnecessary surgical intervention and improve the disease course.