| Literature DB >> 26404892 |
Mio Yano1, Toshihiko Imamura1,2, Daisuke Asai3, Nobutaka Kiyokawa4, Kazuhiko Nakabayashi5, Kenji Matsumoto6, Takao Deguchi2,7, Yoshiko Hashii2,8, Yu-ko Honda2,9, Daiichiro Hasegawa2,10, Yoji Sasahara2,11, Mutsuo Ishii2,12, Yoshiyuki Kosaka2,10, Koji Kato2,13, Midori Shima2,14, Hiroki Hori2,7, Keiko Yumura-Yagi2,15, Junichi Hara2,16, Megumi Oda2,17, Keizo Horibe2,18, Hitoshi Ichikawa19, Atsushi Sato2,20.
Abstract
Activating tyrosine kinase mutations or cytokine receptor signalling alterations have attracted attention as therapeutic targets for high-risk paediatric acute lymphoblastic leukaemia (ALL). We identified two novel kinase fusions, OFD1-JAK2 and NCOR1-LYN, in paediatric ALL patients with IKZF1 deletion, by mRNA sequencing. The patient with CSF2RA-CRLF2 also harboured IGH-EPOR. All these patients had high-risk features, such as high initial white blood cell counts and initial poor response to prednisolone. The functional analysis of these novel fusions is on-going to determine whether these genetic alterations can be targeted by drugs.Entities:
Keywords: IKZF1; Ph-like ALL; kinase fusion; paediatric ALL
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Year: 2015 PMID： 26404892 DOI： 10.1111/bjh.13757
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998