Felix Kreidel1, Christian Frerker2, Michael Schlüter3, Hannes Alessandrini2, Thomas Thielsen2, Stephan Geidel4, Ulrich Schäfer2, Karl-Heinz Kuck2. 1. Department of Cardiology, Asklepios Klinik St. Georg Hospital, Hamburg, Germany. Electronic address: f.kreidel@asklepios.com. 2. Department of Cardiology, Asklepios Klinik St. Georg Hospital, Hamburg, Germany. 3. Asklepios Proresearch, Hamburg, Germany. 4. Department of Cardiac Surgery, Asklepios Klinik St. Georg Hospital, Hamburg, Germany.
Abstract
OBJECTIVES: The goal of this study was to assess procedural details and outcomes of repeat MitraClip therapy. BACKGROUND: MitraClip implantation is a safe and efficacious percutaneous approach to treat significant mitral regurgitation (MR). METHODS: Of 410 inoperable or high surgical risk patients treated with the MitraClip at our institution, 17 (4.1%) patients, as well as 4 patients initially treated at external institutions, underwent repeat MitraClip procedures. Mean age of the 21 patients (14 men [67%]) was 77 years; 15 patients (71%) had functional MR. RESULTS: Repeat procedures performed at a median of 6.3 months (range 0.7 to 34 months) after the index intervention were successful (discharge MR grade ≤2+) in 13 patients (62%), with a pronounced difference in success rate observed between the 13 patients with adequate leaflet insertion at the time of the repeat intervention and the 8 patients in whom loss of leaflet insertion (LLI) (leaflet tear/perforation or partial clip detachment) was present (11 of 13 [85%] vs. 2 of 8 [25%], respectively). The 21 patients were followed for a median of 8.5 (interquartile range: 2.3 to 18.6) months; 13 patients (62%), 8 with adequate leaflet insertion and 5 with LLI, died during follow-up. CONCLUSIONS: Repeat MitraClip intervention for significant recurrent MR appears to be a viable therapeutic approach in patients in whom leaflet insertion into the MitraClip is not compromised. LLI is strongly associated with repeat procedural failure.
OBJECTIVES: The goal of this study was to assess procedural details and outcomes of repeat MitraClip therapy. BACKGROUND: MitraClip implantation is a safe and efficacious percutaneous approach to treat significant mitral regurgitation (MR). METHODS: Of 410 inoperable or high surgical risk patients treated with the MitraClip at our institution, 17 (4.1%) patients, as well as 4 patients initially treated at external institutions, underwent repeat MitraClip procedures. Mean age of the 21 patients (14 men [67%]) was 77 years; 15 patients (71%) had functional MR. RESULTS: Repeat procedures performed at a median of 6.3 months (range 0.7 to 34 months) after the index intervention were successful (discharge MR grade ≤2+) in 13 patients (62%), with a pronounced difference in success rate observed between the 13 patients with adequate leaflet insertion at the time of the repeat intervention and the 8 patients in whom loss of leaflet insertion (LLI) (leaflet tear/perforation or partial clip detachment) was present (11 of 13 [85%] vs. 2 of 8 [25%], respectively). The 21 patients were followed for a median of 8.5 (interquartile range: 2.3 to 18.6) months; 13 patients (62%), 8 with adequate leaflet insertion and 5 with LLI, died during follow-up. CONCLUSIONS: Repeat MitraClip intervention for significant recurrent MR appears to be a viable therapeutic approach in patients in whom leaflet insertion into the MitraClip is not compromised. LLI is strongly associated with repeat procedural failure.
Authors: Michael M Kreusser; Andreas Weber; Nicolas A Geis; Leonie Grossekettler; Martin J Volz; Sonja Hamed; Hugo A Katus; Sven T Pleger; Norbert Frey; Philip W Raake Journal: ESC Heart Fail Date: 2021-09-08
Authors: Guisela Flores; Dolores Mesa; Soledad Ojeda; Javier Suárez de Lezo; Rafael Gonzalez-Manzanares; Guillermo Dueñas; Manuel Pan Journal: J Clin Med Date: 2022-08-14 Impact factor: 4.964
Authors: Katharina Schnitzler; Michaela Hell; Martin Geyer; Felix Kreidel; Thomas Münzel; Ralph Stephan von Bardeleben Journal: Curr Cardiol Rep Date: 2021-08-13 Impact factor: 2.931