| Literature DB >> 26403931 |
Jong Won Kim1, Sung-Kyun Ko2, Sangkeun Son2, Kee-Sun Shin3, In-Ja Ryoo3, Young-Soo Hong2, Hyuncheol Oh4, Bang Yeon Hwang5, Hiroshi Hirota6, Shunji Takahashi6, Bo Yeon Kim2, Hiroyuki Osada7, Jae-Hyuk Jang8, Jong Seog Ahn9.
Abstract
During the chemical investigation of marine-derived fungus, an unusual diketopiperazine (DKP) alkaloid, haenamindole (1), was isolated from a culture of the marine-derived fungus Penicillium sp. KCB12F005. The structure of 1, which possesses benzyl-hydroxypiperazindione and phenyl-pyrimidoindole rings system in the molecule, was elucidated by analysis of NMR and MS data. The stereochemistry of 1 was determined by ROESY and advanced Marfey's method.Entities:
Keywords: Diketopiperazine alkaloid; Marine-derived fungus; Penicillium sp.; Pyrimidoindole; β-Phenylalanine
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Year: 2015 PMID： 26403931 DOI： 10.1016/j.bmcl.2015.09.026
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823