Roxana Desterro E Silva da Cunha1, Fernando Lamy Filho2, Eremita Val Rafael3, Zeni Carvalho Lamy2, André Luiz Guimarães de Queiroz4. 1. Hospital Universitário Materno-Infantil, São Luís, MA, Brazil; Universidade Federal do Maranhão (UFMA), São Luís, MA, Brazil. Electronic address: roxanacunha@hotmail.com. 2. Departamento de Medicina, Universidade Federal do Maranhão (UFMA), São Luís, MA, Brazil. 3. Hospital Universitário Materno-Infantil, São Luís, MA, Brazil; Universidade Federal do Maranhão (UFMA), São Luís, MA, Brazil. 4. Faculdade de Medicina, Universidade Federal do Maranhão (UFMA), São Luís, MA, Brazil; Institutional Program for Scientific Initiation Scholarships (PIBIC), Brazil.
Abstract
OBJECTIVES: To assess the effect of maternal breast milk supplementation on the development of exclusively breast-fed very low birth weight preterm infants at 12 months of corrected age. METHODS: A randomized clinical trial with 53 infants followed-up after discharge from the neonatal unit until a corrected gestational age of 12 months. Newborns in the intervention group were breastfed exclusively with maternal milk and received 2g of a multinutrient supplement (Pré-Nan(®), Nestlé, Vevey, Switzerland) added to expressed breast milk twice a day until a corrected age of 4-6 months. The control group was exclusively breastfed without supplementation. After monthly follow-up, developmental assessment was performed using the Bayley III Scale. RESULTS: There was no statistically significant difference on the Bayley III Scale between the intervention and control groups in any of the assessed domains: motor, cognitive, and communication. However, scores in the three domains were always higher in the group that received the supplement. There were a similar number of cases of developmental delay in both groups: seven (28%) in the group that received the supplement and nine (33.3%) in the group that was exclusively breastfed. CONCLUSIONS: The results failed to show an association between post-discharge multinutrient supplementation and development in the assessed infants.
RCT Entities:
OBJECTIVES: To assess the effect of maternal breast milk supplementation on the development of exclusively breast-fed very low birth weight preterm infants at 12 months of corrected age. METHODS: A randomized clinical trial with 53 infants followed-up after discharge from the neonatal unit until a corrected gestational age of 12 months. Newborns in the intervention group were breastfed exclusively with maternal milk and received 2g of a multinutrient supplement (Pré-Nan(®), Nestlé, Vevey, Switzerland) added to expressed breast milk twice a day until a corrected age of 4-6 months. The control group was exclusively breastfed without supplementation. After monthly follow-up, developmental assessment was performed using the Bayley III Scale. RESULTS: There was no statistically significant difference on the Bayley III Scale between the intervention and control groups in any of the assessed domains: motor, cognitive, and communication. However, scores in the three domains were always higher in the group that received the supplement. There were a similar number of cases of developmental delay in both groups: seven (28%) in the group that received the supplement and nine (33.3%) in the group that was exclusively breastfed. CONCLUSIONS: The results failed to show an association between post-discharge multinutrient supplementation and development in the assessed infants.
Authors: Shoshana H Bardach; Amanda N Perry; Nirav S Kapadia; Kathryn E Richards; Laura K Cogswell; Tyler K Hartman Journal: BMJ Open Qual Date: 2022-05
Authors: Isabella Nascimento Alves Ferreira; Fernanda Valente Mendes Soares; Ana Carolina Carioca da Costa; Maria Elisabeth Lopes Moreira Journal: Rev Paul Pediatr Date: 2018-11-14
Authors: Luling Lin; Greg D Gamble; Caroline A Crowther; Frank H Bloomfield; Massimo Agosti; Stephanie A Atkinson; Augusto Biasini; Nicholas D Embleton; Mary S Fewtrell; Fernando Lamy-Filho; Christoph Fusch; Maria L Gianni; H Gozde Kanmaz Kutman; Winston Koo; Ita Litmanovitz; Colin Morgan; Kanya Mukhopadhyay; Erica Neri; Jean-Charles Picaud; Niels Rochow; Paola Roggero; Atul Singhal; Kenneth Stroemmen; Maw J Tan; Francesco M Tandoi; Claire L Wood; Gitte Zachariassen; Jane E Harding Journal: Nutrients Date: 2022-01-18 Impact factor: 5.717