| Literature DB >> 26403416 |
S Nisticò1, J Ehrlich2, M Gliozzi3, J Maiuolo3, E Del Duca1, C Muscoli3, V Mollace2.
Abstract
Photoageing represents the addition of extrinsic chronic ultraviolet radiation-induced damage on intrinsic ageing and accounts for most age-associated changes in skin appearance. In this study, we evaluated the effect of 38% BPF, a highly concentrated extract of the bergamot fruit (Citrus bergamia) on UVB-induced photoageing by examining inflammatory cytokine expression, telomere length/telomerase alterations and cellular viability in human immortalized HaCaT keratinocytes. Our results suggest that 38% BPF protects HaCaT cells against UVB-induced oxidative stress and markers of photoageing in a dose-dependent manner and could be a useful supplement in skin care products. Together with antioxidant properties, BPF, a highly concentrated extract of the bergamot fruit, appears to modulate basic cellular signal transduction pathways leading to anti-proliferative, anti-aging and immune modulating responses.Entities:
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Year: 2015 PMID： 26403416
Source DB: PubMed Journal: J Biol Regul Homeost Agents ISSN： 0393-974X Impact factor: 1.711