Literature DB >> 26402754

Statin Use is Associated with Better Cognitive Function in Elderly with Type 2 Diabetes.

Anthony D Heymann1,2, Ramit Ravona-Springer3, Erin L Moshier4, James Godbold4, Michal Schnaider Beeri5,6.   

Abstract

The pleiotropic contribution of statins on cognition is uncertain. From 840 patients in the cohort from the Israel Diabetes and Cognitive Decline Study, we identified 61 non-statin users and compared them with 45 patients who had used statins at least 90% of the time. Analysis of covariance was performed to compare mean cognitive z-scores between statin users and non-users while adjusting for socio-demographic, diabetes-related, and cardiovascular covariates which included change in cholesterol by year. Overall cognition, memory, and executive function was found to be significantly better in statin users (p <  0.0008). This suggests a positive effect of statins on cognitive function of type 2 diabetes patients that is independent of cholesterol levels.

Entities:  

Keywords:  All cognitive disorders/dementia; Alzheimer’s disease; case control studies; diabetes

Mesh：

Substances：

Year:  2015        PMID： 26402754      PMCID： PMC5753415          DOI： 10.3233/JAD-142571

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN： 1387-2877            Impact factor:   4.472


  12 in total

1.  The Israel Diabetes and Cognitive Decline (IDCD) study: Design and baseline characteristics.

Authors:  Michal Schnaider Beeri; Ramit Ravona-Springer; Erin Moshier; James Schmeidler; James Godbold; Tomas Karpati; Derek Leroith; Keren Koifman; Efrat Kravitz; Rachel Price; Hadas Hoffman; Jeremy M Silverman; Anthony Heymann
Journal:  Alzheimers Dement       Date:  2014-08-20       Impact factor: 21.566

2.  Association of diabetes mellitus and dementia: the Rotterdam Study.

Authors:  A Ott; R P Stolk; A Hofman; F van Harskamp; D E Grobbee; M M Breteler
Journal:  Diabetologia       Date:  1996-11       Impact factor: 10.122

Review 3.  Statins and cognitive function: a systematic review.

Authors:  Karl Richardson; Marisa Schoen; Benjamin French; Craig A Umscheid; Matthew D Mitchell; Steven E Arnold; Paul A Heidenreich; Daniel J Rader; Emil M deGoma
Journal:  Ann Intern Med       Date:  2013-11-19       Impact factor: 25.391

Review 4.  Statins for the treatment of dementia.

Authors:  Bernadette McGuinness; John O'Hare; David Craig; Roger Bullock; Reem Malouf; Peter Passmore
Journal:  Cochrane Database Syst Rev       Date:  2010-08-04

5.  Statins, risk of dementia, and cognitive function: secondary analysis of the ginkgo evaluation of memory study.

Authors:  Kerstin Bettermann; Alice M Arnold; Jeff Williamson; Stephen Rapp; Kaycee Sink; James F Toole; Michelle C Carlson; Sevil Yasar; Steven Dekosky; Gregory L Burke
Journal:  J Stroke Cerebrovasc Dis       Date:  2011-01-14       Impact factor: 2.136

6.  Age, gender, and education are associated with cognitive performance in an older Israeli sample with type 2 diabetes.

Authors:  Elizabeth Guerrero-Berroa; Ramit Ravona-Springer; James Schmeidler; Jeremy M Silverman; Mary Sano; Keren Koifmann; Rachel Preiss; Hadas Hoffman; Anthony Heymann; Michal Schnaider Beeri
Journal:  Int J Geriatr Psychiatry       Date:  2013-08-08       Impact factor: 3.485

7.  Pravastatin in elderly individuals at risk of vascular disease (PROSPER): a randomised controlled trial.

Authors:  James Shepherd; Gerard J Blauw; Michael B Murphy; Edward L E M Bollen; Brendan M Buckley; Stuart M Cobbe; Ian Ford; Allan Gaw; Michael Hyland; J Wouter Jukema; Adriaan M Kamper; Peter W Macfarlane; A Edo Meinders; John Norrie; Chris J Packard; Ivan J Perry; David J Stott; Brian J Sweeney; Cillian Twomey; Rudi G J Westendorp
Journal:  Lancet       Date:  2002-11-23       Impact factor: 79.321

Review 8.  Statins for the treatment of dementia.

Authors:  Bernadette McGuinness; David Craig; Roger Bullock; Reem Malouf; Peter Passmore
Journal:  Cochrane Database Syst Rev       Date:  2014-07-08

9.  Life long changes in cognitive ability are associated with prescribed medications in old age.

Authors:  John M Starr; Brian McGurn; Martha Whiteman; Alison Pattie; Lawrence J Whalley; Ian J Deary
Journal:  Int J Geriatr Psychiatry       Date:  2004-04       Impact factor: 3.485

10.  The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials.

Authors:  B Mihaylova; J Emberson; L Blackwell; A Keech; J Simes; E H Barnes; M Voysey; A Gray; R Collins; C Baigent
Journal:  Lancet       Date:  2012-05-17       Impact factor: 79.321
View more
  2 in total

1.  PoLA/CFPiP/PCS Guidelines for the Management of Dyslipidaemias for Family Physicians 2016.

Authors:  Maciej Banach; Piotr Jankowski; Jacek Jóźwiak; Barbara Cybulska; Adam Windak; Tomasz Guzik; Artur Mamcarz; Marlena Broncel; Tomasz Tomasik; Jacek Rysz; Agnieszka Jankowska-Zduńczyk; Piotr Hoffman; Agnieszka Mastalerz-Migas
Journal:  Arch Med Sci       Date:  2016-12-19       Impact factor: 3.318

Review 2.  Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer's disease.

Authors:  Lin Jia; Juan Piña-Crespo; Yonghe Li
Journal:  Mol Brain       Date:  2019-12-04       Impact factor: 4.041
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.