Nina Gramunt1, Herman Buschke2, Gonzalo Sánchez-Benavides1,3, Richard B Lipton2, Jordi Peña-Casanova4, Faustino Diéguez-Vide5, Xavier Masramon6, Juan D Gispert1, Karine Fauria1, Jordi Camí7,8, José L Molinuevo1. 1. Clinical Research Program, BarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain. 2. Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA. 3. Hospital del Mar Research Institute (IMIM), Barcelona, Spain. 4. Department of Behavioral Neurology, Service of Neurology, Hospital del Mar, Parc Salut Mar, Barcelona, Spain. 5. General Linguistics Department, University of Barcelona, Barcelona, Spain. 6. SAIL Statistics, Barcelona, Spain. 7. Pasqual Maragall Foundation, Barcelona, Spain. 8. Universitat Pompeu Fabra, Barcelona, Spain.
Abstract
BACKGROUND: The Memory Binding Test (MBT) is a novel test based on the learning of two lists of words, developed to detect early memory impairment suggestive of Alzheimer's disease (AD). OBJECTIVE: To present and provide reference data of the Spanish MBT in a midlife population of mainly first-degree descendants of AD patients. METHODS: 472 cognitively unimpaired subjects, aged 45 to 65 and participants of the ALFA STUDY, were included. Raw scores were transformed to scaled scores on which multivariate regression analysis was applied adjusting by age, gender, and education level. A standard linear regression was employed to derive the scaled score adjusted. Sociodemographic corrections were applied and an adjustment table was constructed. RESULTS: Performance was heterogeneously influenced by sociodemographic factors. Age negatively influenced free recall. Education tends to have an influence in the results showing lower performance with lower education level. Women tend to outperform men in the learning of the first list and total recall. Only a few variables were unaffected by sociodemographic factors such as those related to semantic proactive interference (SPI) and to the retention of learned material. Our results point out that some vulnerability to SPI is expectable in cognitively healthy subjects. Close to 100% of the learned material was maintained across the delay interval. CONCLUSION: This study contributes with reference data for the MBT providing the necessary adjustments for sociodemographic characteristics. Our data may prove to be useful for detecting asymptomatic at-risk candidates for secondary prevention studies of AD.
BACKGROUND: The Memory Binding Test (MBT) is a novel test based on the learning of two lists of words, developed to detect early memory impairment suggestive of Alzheimer's disease (AD). OBJECTIVE: To present and provide reference data of the Spanish MBT in a midlife population of mainly first-degree descendants of ADpatients. METHODS: 472 cognitively unimpaired subjects, aged 45 to 65 and participants of the ALFA STUDY, were included. Raw scores were transformed to scaled scores on which multivariate regression analysis was applied adjusting by age, gender, and education level. A standard linear regression was employed to derive the scaled score adjusted. Sociodemographic corrections were applied and an adjustment table was constructed. RESULTS: Performance was heterogeneously influenced by sociodemographic factors. Age negatively influenced free recall. Education tends to have an influence in the results showing lower performance with lower education level. Women tend to outperform men in the learning of the first list and total recall. Only a few variables were unaffected by sociodemographic factors such as those related to semantic proactive interference (SPI) and to the retention of learned material. Our results point out that some vulnerability to SPI is expectable in cognitively healthy subjects. Close to 100% of the learned material was maintained across the delay interval. CONCLUSION: This study contributes with reference data for the MBT providing the necessary adjustments for sociodemographic characteristics. Our data may prove to be useful for detecting asymptomatic at-risk candidates for secondary prevention studies of AD.
Authors: Herman Buschke; Wenzhu B Mowrey; Wendy S Ramratan; Molly E Zimmerman; David A Loewenstein; Mindy J Katz; Richard B Lipton Journal: Arch Clin Neuropsychol Date: 2016-09-27 Impact factor: 2.813
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Authors: Anna Brugulat-Serrat; Gemma Salvadó; Carole H Sudre; Oriol Grau-Rivera; Marc Suárez-Calvet; Carles Falcon; Gonzalo Sánchez-Benavides; Nina Gramunt; Karine Fauria; M Jorge Cardoso; Frederik Barkhof; José Luis Molinuevo; Juan Domingo Gispert Journal: Brain Imaging Behav Date: 2020-10 Impact factor: 3.978
Authors: Anna Brugulat-Serrat; Alba Cañas-Martínez; Lidia Canals-Gispert; Paula Marne; Nina Gramunt; Marta Milà-Alomà; Marc Suárez-Calvet; Eider M Arenaza-Urquijo; Oriol Grau-Rivera; José María González-de-Echávarri; Carolina Minguillon; Karine Fauria; Gwendlyn Kollmorgen; Ivonne Suridjan; Henrik Zetterberg; Kaj Blennow; Juan Domingo Gispert; José Luis Molinuevo; Gonzalo Sánchez-Benavides Journal: J Alzheimers Dis Date: 2021 Impact factor: 4.472