Shinji Matsunaga1, Taro Kishi1, Peter Annas2, Hans Basun3,4, Harald Hampel5, Nakao Iwata1. 1. Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. 2. Department of Psychology, Uppsala University, Uppsala, Sweden. 3. Department of Public Care and Family Medicine, Section of Geriatric Medicine, Uppsala University, Uppsala, Sweden. 4. BioArctic Neuroscience AB, Stockholm, Sweden. 5. AXA Research Fund and UPMC Chair, Sorbonne Universités,Université Pierre et Marie Curie, Paris 06, Institut de la Mémoire et de la Maladie d'Alzheimer & INSERM U1127, Institut du Cerveau et de la Moelle épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpétrière, Paris, France.
Abstract
BACKGROUND: This is the first meta-analysis of randomized placebo-controlled trials testing lithium as a treatment for patients with Alzheimer's disease (AD) and individuals with mild cognitive impairment (MCI). METHODS: The primary outcome measure was efficacy on cognitive performance as measured through the Alzheimer's Disease Assessment Scale cognitive subscale or the Mini-Mental State Examination. Other outcome measures were drug discontinuation rate, individual side effects, and biological markers (phosphorylated tau 181, total tau, and amyloid-β42) in cerebrospinal fluid (CSF). RESULTS: Three clinical trials including 232 participants that met the study's inclusion criteria were identified. Lithium significantly decreased cognitive decline as compared to placebo (standardized mean difference = -0.41, 95% confidence interval = -0.81 to -0.02, p = 0.04, I2 = 47% , 3 studies, n = 199). There were no significant differences in the rate of attrition, discontinuation due to all causes or adverse events, or CSF biomarkers between treatment groups. CONCLUSIONS: The results indicate that lithium treatment may have beneficial effects on cognitive performance in subjects with MCI and AD dementia.
BACKGROUND: This is the first meta-analysis of randomized placebo-controlled trials testing lithium as a treatment for patients with Alzheimer's disease (AD) and individuals with mild cognitive impairment (MCI). METHODS: The primary outcome measure was efficacy on cognitive performance as measured through the Alzheimer's Disease Assessment Scale cognitive subscale or the Mini-Mental State Examination. Other outcome measures were drug discontinuation rate, individual side effects, and biological markers (phosphorylated tau 181, total tau, and amyloid-β42) in cerebrospinal fluid (CSF). RESULTS: Three clinical trials including 232 participants that met the study's inclusion criteria were identified. Lithium significantly decreased cognitive decline as compared to placebo (standardized mean difference = -0.41, 95% confidence interval = -0.81 to -0.02, p = 0.04, I2 = 47% , 3 studies, n = 199). There were no significant differences in the rate of attrition, discontinuation due to all causes or adverse events, or CSF biomarkers between treatment groups. CONCLUSIONS: The results indicate that lithium treatment may have beneficial effects on cognitive performance in subjects with MCI and AD dementia.
Authors: Katherine E Burdick; Caitlin E Millett; Manuela Russo; Martin Alda; Ney Alliey-Rodriguez; Amit Anand; Yokesh Balaraman; Wade Berrettini; Holli Bertram; Joseph R Calabrese; Cynthia Calkin; Carla Conroy; William Coryell; Anna DeModena; Scott Feeder; Carrie Fisher; Nicole Frazier; Mark Frye; Keming Gao; Julie Garnham; Elliot S Gershon; Kara Glazer; Fernando S Goes; Toyomi Goto; Gloria J Harrington; Petter Jakobsen; Masoud Kamali; Marisa Kelly; Susan Leckband; Else Marie Løberg; Falk W Lohoff; Adam X Maihofer; Michael J McCarthy; Melvin McInnis; Gunnar Morken; Caroline M Nievergelt; John Nurnberger; Ketil J Oedegaard; Abigail Ortiz; Megan Ritchey; Kelly Ryan; Martha Schinagle; Candice Schwebel; Martha Shaw; Paul Shilling; Claire Slaney; Emma Stapp; Bruce Tarwater; Peter Zandi; John R Kelsoe Journal: Neuropsychopharmacology Date: 2020-04-29 Impact factor: 7.853
Authors: Md Sahab Uddin; Anna Stachowiak; Abdullah Al Mamun; Nikolay T Tzvetkov; Shinya Takeda; Atanas G Atanasov; Leandro B Bergantin; Mohamed M Abdel-Daim; Adrian M Stankiewicz Journal: Front Aging Neurosci Date: 2018-01-30 Impact factor: 5.750