| Literature DB >> 26401840 |
Miroslaw Janczura, Grazyna Bochenek, Roman Nowobilski, Jerzy Dropinski, Katarzyna Kotula-Horowitz, Bartosz Laskowicz, Andrzej Stanisz, Jacek Lelakowski, Teresa Domagala.
Abstract
Entities:
Year: 2015 PMID： 26401840 PMCID： PMC4581714 DOI： 10.1371/journal.pone.0139408
Source DB: PubMed Journal: PLoS One ISSN： 1932-6203 Impact factor: 3.240
Clinical characteristics of the study subjects.
| Study variable | Value |
|---|---|
| N (F) | 235 (19) |
| Age, years | 40.97 (6.26) |
| Framingham Risk Score | 5.82 (5.11) |
| W/H ratio | 0.94 (0.06) |
| Overweight, n (%) | 101 (42.97) |
| Obesity, n (%) | 103 (43.83) |
| Dyslipidemia, n (%) | 120 (51.06) |
| Diabetes mellitus, n (%) | 7 (2.97) |
| Hypertension, n (%) | 104 (44.25) |
| Stable CHD, n (%) | 17 (7.23) |
| Positive family history of CHD, n (%) | 128 (54.46) |
| History of myocardial infarction, n (%) | 1 (0.42) |
| PCI, n (%) | 5 (2.13) |
| Smoking status, n (%) | |
| Never, Current, Past, Pack-years | 96 (40.85), 79 (33.62), 60 (25.53), 17.68 (11.83) |
| COPD, n (%) | 0 |
| Treatments, n (%) | |
| Aspirin, ACEI/ARB, β-blocker, Ca-blocker, Diuretics, Lipid-lowering drugs, Anti diabetic drugs | 8 (3.40), 44 (18.72), 42 (17.87), 14 (5.97), 30 (12.76), 13 (5.53), 7 (2.97) |
* Data are expressed as mean (SD); Framingham Risk Score, 10-year risk of developing coronary heart disease; W/H ratio, waist/hip; CHD, coronary heart disease; PCI, percutaneous coronary intervention; BMI, body mass index; ACEI, Angiotensin converting enzyme inhibitors; ARB, Angiotensin II receptor blockers; COPD, chronic obstructive pulmonary disease.
Obesity was defined as BMI>30.0 kg/m2 and overweight as BMI >25.0 kg/m2.
Characteristics of the study subjects stratified by metabolic syndrome status.
| Study variable | Metabolic Syndrome | Non-Metabolic Syndrome | p value |
|---|---|---|---|
| N (F) | 109 (4) | 126 (15) | 0.038 |
| Age, years | 42.54 (6.75) | 39.61 (5.48) | <0.001 |
| Framingham Risk Score | 8.32 (5.26) | 3.43 (2.99) | <0.0001 |
| BMI, kg/m2 | 32.27 (3.73) | 27.78 (3.28) | <0.0001 |
| W/H ratio | 0.98 (0.04) | 0.91(0.06) | <0.0001 |
| Systolic blood pressure, mm Hg | 137.93 (16.93) | 124.15 (15.53) | <0.0001 |
| Diastolic blood pressure, mm Hg | 87.66 (10.48) | 80.36 (9.79) | <0.0001 |
| Stable CHD, n (%) | 12 (11.01) | 5 (3.96) | 0.053 |
| Positive result of stress ECG; n (%) | 18 (18.37) | 7 (6.60) | 0.012 |
| Coronary plaque burden, n (%) | 29 (37.66) | 14 (18.18) | 0.007 |
| FMD, % | 7.80 (3.23) | 8.17 (3.71) | 0.59 |
| IMT, mm | 0.59 (0.10) | 0.54 (0.09) | 0.0002 |
| Smoking status, n (%) | |||
| Never, Current, Past | 35 (32.11), 40 (36.69), 34 (31.19) | 61 (48.41), 39 (30.95), 26 (20.63) | 0.01, 0.35, 0.06 |
| Total cholesterol, mmol/L | 5.61 (1.01) | 5.02 (0.88) | <0.0001 |
| LDL cholesterol, mmol/L | 3.25 (0.86) | 3.02 (0.76) | 0.056 |
| HDL cholesterol, mmol/L | 1.12 (0.25) | 1.37 (0.35) | <0.0001 |
| Triglycerides, mmol/L | 2.92 (1.76) | 1.35 (0.75) | <0.0001 |
| Glucose, mmol/L | 5.72 (1.29) | 5.08 (0.39) | <0.0001 |
| CRP, mg/L | 2.18 (2.35) | 1.55 (1.78) | 0.0001 |
| TNF-α, pg/mL | 1.70 (2.85) | 1.25 (2.04) | 0.06 |
Data are expressed as mean (SD); BMI, body mass index; W/H, waist/hip; CHD, coronary heart disease; FMD, flow-mediated dilation; IMT, intima-media thickness; LDL, low density lipoprotein; HDL, high density lipoprotein; CRP, C-reactive protein; TNF-α, tissue necrotic factor-α;
* n (%) subjects who underwent stress ECG;
** n (%) subjects who underwent computed tomography coronary angiography.