Literature DB >> 26401027

Helicobacter pylori cagA Promoter Region Sequences Influence CagA Expression and Interleukin 8 Secretion.

Rui M Ferreira1, Ines Pinto-Ribeiro1, Xiaogang Wen2, Ricardo Marcos-Pinto3, Mário Dinis-Ribeiro4, Fátima Carneiro5, Ceu Figueiredo6.   

Abstract

Heterogeneity at the Helicobacter pylori cagA gene promoter region has been linked to variation in CagA expression and gastric histopathology. Here, we characterized the cagA promoter and expression in 46 H. pylori strains from Portugal. Our results confirm the relationship between cagA promoter region variation and protein expression originally observed in strains from Colombia. We observed that individuals with intestinal metaplasia were all infected with H. pylori strains containing a specific cagA motif. Additionally, we provided novel functional evidence that strain-specific sequences in the cagA promoter region and CagA expression levels influence interleukin 8 secretion by the host gastric epithelial cells.
© The Author 2015. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

Entities:  

Keywords:  CagA expression; Helicobacter pylori; IL-8; cagA promoter region

Mesh：

Substances：

Year:  2015        PMID： 26401027     DOI： 10.1093/infdis/jiv467

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  19 in total

1.  Role of a Stem-Loop Structure in Helicobacter pylori cagA Transcript Stability.

Authors:  John T Loh; Aung Soe Lin; Amber C Beckett; Mark S McClain; Timothy L Cover
Journal:  Infect Immun       Date:  2019-01-24       Impact factor: 3.441

Review 2.  Genetic populations and virulence factors of Helicobacter pylori.

Authors:  Evariste Tshibangu Kabamba; Vo Phuoc Tuan; Yoshio Yamaoka
Journal:  Infect Genet Evol       Date:  2018-02-19       Impact factor: 3.342

3.  H. pylori Infection and Virulence Factors cagA and vacA (s and m Regions) in Gastric Adenocarcinoma from Pará State, Brazil.

Authors:  Igor Brasil-Costa; Cintya de Oliveira Souza; Leni Célia Reis Monteiro; Maria Elisabete Silva Santos; Edivaldo Herculano Correa De Oliveira; Rommel Mario Rodriguez Burbano
Journal:  Pathogens       Date:  2022-03-29

4.  Helicobacter pylori vacA Genotypes in Chronic Gastritis and Gastric Carcinoma Patients from Macau, China.

Authors:  Ines Pinto-Ribeiro; Rui M Ferreira; Sellma Batalha; Thazin Hlaing; Sio In Wong; Fatima Carneiro; Ceu Figueiredo
Journal:  Toxins (Basel)       Date:  2016-05-05       Impact factor: 4.546

5.  Helicobacter pylori and Gastric Cancer.

Authors:  Amin Talebi Bezmin Abadi
Journal:  Front Med (Lausanne)       Date:  2016-08-22

6.  Helicobacter pylori modulates host cell responses by CagT4SS-dependent translocation of an intermediate metabolite of LPS inner core heptose biosynthesis.

Authors:  Saskia C Stein; Eugenia Faber; Simon H Bats; Tatiana Murillo; Yvonne Speidel; Nina Coombs; Christine Josenhans
Journal:  PLoS Pathog       Date:  2017-07-17       Impact factor: 6.823

7.  Petri Net-Based Model of Helicobacter pylori Mediated Disruption of Tight Junction Proteins in Stomach Lining during Gastric Carcinoma.

Authors:  Anam Naz; Ayesha Obaid; Faryal M Awan; Aqsa Ikram; Jamil Ahmad; Amjad Ali
Journal:  Front Microbiol       Date:  2017-09-06       Impact factor: 5.640

Review 8.  Helicobacter pylori Strains and Gastric MALT Lymphoma.

Authors:  Pauline Floch; Francis Mégraud; Philippe Lehours
Journal:  Toxins (Basel)       Date:  2017-04-08       Impact factor: 4.546

Review 9.  Microbial carcinogenic toxins and dietary anti-cancer protectants.

Authors:  Trevor W Stone; L Gail Darlington
Journal:  Cell Mol Life Sci       Date:  2017-02-25       Impact factor: 9.261

Review 10.  Helicobacter pylori Diversity and Gastric Cancer Risk.

Authors:  Timothy L Cover
Journal:  MBio       Date:  2016-01-26       Impact factor: 7.867
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