Emanuele Pravatà1,2, Joshua Tavernier3, Ryan Parker4, Hrvoje Vavro5, Jacobo E Mintzer6, Maria Vittoria Spampinato3. 1. Department of Radiology and Radiological Sciences, Medical University of South Carolina, Charleston, SC, USA. emanuele.pravata@gmail.com. 2. Department of Neuroradiology, Neurocenter of Southern Switzerland, Ospedale Regionale di Lugano, Via Tesserete 46, 6900, Lugano, Switzerland. emanuele.pravata@gmail.com. 3. Department of Radiology and Radiological Sciences, Medical University of South Carolina, Charleston, SC, USA. 4. Department of Anesthesiology, Vanderbilt University, Nashville, TN, USA. 5. University Hospital Dubrava, Zagreb, Croatia. 6. Clinical Biotechnology Research Institute, Roper Hospital, Charleston, SC, USA.
Abstract
INTRODUCTION: Language impairment is frequently observed in patients with Alzheimer's disease (AD): in this study, we investigated the extent and distribution of brain atrophy in subjects with conversion from mild cognitive impairment (MCI) to AD with and without naming difficulties. METHODS: This study was approved by the institutional review board and was HIPAA compliant. All subjects or their legal representatives gave informed consent for participation. Ninety-one subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) with (N = 51) and without (N = 40) naming impairment as per the Boston Naming Test (BNT), underwent brain magnetic resonance (MR) imaging 12 months before, at AD diagnosis, and 12 months after. Structural MR images were processed using voxel-based morphometry. Cross-sectional comparisons and mixed ANOVA models for assessing regional gray matter (GM) volume differences were performed. RESULTS: As from 12 months prior to AD diagnosis, patients with naming difficulties showed distinct areas of greater GM loss in the left fusiform gyrus (Brodmann area 20) than patients without naming difficulties. Differences in the GM atrophy extended to the left hemisphere in the subsequent 12 months. CONCLUSION: This study provided evidence of distinct patterns and dynamics of brain atrophy in AD patients with naming difficulties when compared to those with intact language, as early as 12 months prior to AD diagnosis and in the subsequent 12 months.
INTRODUCTION:Language impairment is frequently observed in patients with Alzheimer's disease (AD): in this study, we investigated the extent and distribution of brain atrophy in subjects with conversion from mild cognitive impairment (MCI) to AD with and without naming difficulties. METHODS: This study was approved by the institutional review board and was HIPAA compliant. All subjects or their legal representatives gave informed consent for participation. Ninety-one subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) with (N = 51) and without (N = 40) naming impairment as per the Boston Naming Test (BNT), underwent brain magnetic resonance (MR) imaging 12 months before, at AD diagnosis, and 12 months after. Structural MR images were processed using voxel-based morphometry. Cross-sectional comparisons and mixed ANOVA models for assessing regional gray matter (GM) volume differences were performed. RESULTS: As from 12 months prior to AD diagnosis, patients with naming difficulties showed distinct areas of greater GM loss in the left fusiform gyrus (Brodmann area 20) than patients without naming difficulties. Differences in the GM atrophy extended to the left hemisphere in the subsequent 12 months. CONCLUSION: This study provided evidence of distinct patterns and dynamics of brain atrophy in ADpatients with naming difficulties when compared to those with intact language, as early as 12 months prior to AD diagnosis and in the subsequent 12 months.
Entities:
Keywords:
Alzheimer’s disease; Anomia; Language; Magnetic resonance imaging; Voxel-based morphometry
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