Haidong Li1, Zhiying Zhang1, Xiuchao Zhao1, Xianping Sun1, Chaohui Ye1, Xin Zhou1. 1. Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, 430071, P. R. China.
Abstract
PURPOSE: To demonstrate the feasibility of quantitative and comprehensive global evaluation of pulmonary function and microstructural changes in rats with radiation-induced lung injury (RILI) using hyperpolarized xenon MR. METHODS: Dissolved xenon spectra were dynamically acquired using a modified chemical shift saturation recovery pulse sequence in five rats with RILI (bilaterally exposed by 6-MV x-ray with a dose of 14 Gy 3 mo. prior to MR experiments) and five healthy rats. The dissolved xenon signals were quantitatively analyzed, and the pulmonary physiological parameters were extracted with the model of xenon exchange. RESULTS: The obtained pulmonary physiological parameters and the ratio of (129) Xe signal in red blood cells (RBCs) versus barrier showed a significant difference between the groups. In RILI rats versus controls, the exchange time increased from 44.5 to 112 ms, the pulmonary capillary transit time increased from 0.51 to 1.48 s, and the ratio of (129) Xe spectroscopic signal in RBCs versus barrier increased from 0.294 to 0.484. CONCLUSION: Hyperpolarized xenon MR is effective for quantitative and comprehensive global evaluation of pulmonary function and structural changes without the use of radiation. This may open the door for its use in the diagnosis of lung diseases that are related to gas exchange. Magn Reson Med 76:408-416, 2016.
PURPOSE: To demonstrate the feasibility of quantitative and comprehensive global evaluation of pulmonary function and microstructural changes in rats with radiation-induced lung injury (RILI) using hyperpolarized xenon MR. METHODS: Dissolved xenon spectra were dynamically acquired using a modified chemical shift saturation recovery pulse sequence in five rats with RILI (bilaterally exposed by 6-MV x-ray with a dose of 14 Gy 3 mo. prior to MR experiments) and five healthy rats. The dissolved xenon signals were quantitatively analyzed, and the pulmonary physiological parameters were extracted with the model of xenon exchange. RESULTS: The obtained pulmonary physiological parameters and the ratio of (129) Xe signal in red blood cells (RBCs) versus barrier showed a significant difference between the groups. In RILI rats versus controls, the exchange time increased from 44.5 to 112 ms, the pulmonary capillary transit time increased from 0.51 to 1.48 s, and the ratio of (129) Xe spectroscopic signal in RBCs versus barrier increased from 0.294 to 0.484. CONCLUSION: Hyperpolarized xenon MR is effective for quantitative and comprehensive global evaluation of pulmonary function and structural changes without the use of radiation. This may open the door for its use in the diagnosis of lung diseases that are related to gas exchange. Magn Reson Med 76:408-416, 2016.
Authors: Mehrdad Pourfathi; Yi Xin; Stephen J Kadlecek; Maurizio F Cereda; Harrilla Profka; Hooman Hamedani; Sarmad M Siddiqui; Kai Ruppert; Nicholas A Drachman; Jennia N Rajaei; Rahim R Rizi Journal: Magn Reson Med Date: 2017-01-11 Impact factor: 4.668
Authors: Kai Ruppert; Faraz Amzajerdian; Yi Xin; Hooman Hamedani; Luis Loza; Tahmina Achekzai; Ian F Duncan; Harrilla Profka; Yiwen Qian; Mehrdad Pourfathi; Stephen Kadlecek; Rahim R Rizi Journal: Magn Reson Med Date: 2020-06-18 Impact factor: 4.668
Authors: Kai Ruppert; Yi Xin; Hooman Hamedani; Faraz Amzajerdian; Luis Loza; Tahmina Achekzai; Ian F Duncan; Harrilla Profka; Sarmad Siddiqui; Mehrdad Pourfathi; Federico Sertic; Maurizio F Cereda; Stephen Kadlecek; Rahim R Rizi Journal: Sci Rep Date: 2019-02-20 Impact factor: 4.379