| Literature DB >> 26399452 |
Bruno Amato1,2, Rita Compagna1,2, Maurizio Amato2, Lucia Butrico3, Francesco Fugetto4, Mariia D Chibireva5, Andrea Barbetta3, Marco Cannistrà6, Stefano de Franciscis1,3, Raffaele Serra1,3.
Abstract
Wound healing is an articulated process that can be impaired in different steps in chronic wounds. Chronic leg ulcers are a special type of non-healing wounds that represent an important cause of morbidity and public cost in western countries. Because of their common recurrence after conventional managements and increasing prevalence due to an ageing population, newer approaches are needed. Over the last decade, the research has been focused on innovative treatment strategies, including stem-cell-based therapies. After the initial interest in embryonic pluripotent cells, several different types of adult stem cells have been studied because of ethical issues. Specific types of adult stem cells have shown a high potentiality in tissue healing, in both in vitro and in vivo studies. Aim of this review is to clearly report the newest insights on tissue regeneration medicine, with particular regard for chronic leg ulcers.Entities:
Keywords: Adult tissue-derived stem cells; Chronic leg ulcers; Stem cells; Wound healing
Mesh：
Year: 2015 PMID： 26399452 PMCID： PMC7949523 DOI： 10.1111/iwj.12499
Source DB: PubMed Journal: Int Wound J ISSN： 1742-4801 Impact factor: 3.315