Jan J Jobsen1, Job van der Palen2,3, Mariël Brinkhuis4, Francisca Ong1, Henk Struikmans5,6. 1. a Department of Radiation Oncology , Medisch Spectrum Twente , Enschede , The Netherlands . 2. b Department of Epidemiology , Medisch Spectrum Twente , Enschede , The Netherlands . 3. c Departement of Research Methodology, Measurement, and Data Analysis , Faculty of Behavioral Science, University of Twente , The Netherlands . 4. d Laboratory for Pathology Oost Nederland , Hengelo , The Netherlands . 5. e Department of Radiation Oncology , Leiden University Medical Centre , Leiden , The Netherlands , and. 6. f Radiotherapy Centre West, Medical Centre Haaglanden , The Hague , The Netherlands.
Abstract
BACKGROUND: The aim of this study is to analyze the impact of first degree relative (FDR) of young breast cancer patients. METHODS: Data were used from our prospective population-based cohort study which started in 1983. The family history (FH) was registered with regard to FDR: the presence or absence of invasive breast cancer in none vs. one or more FDRs at any age. RESULTS: A total of 1109 women, ≤50 years with 1128 breast conserving treatments was seen. The incidence of FDR was 17.0% for one FDR and 3.2% ≥2 FDR. The three groups, none, 1 or ≥2 FDR, were comparable. The local failure rate is comparable for all three groups. Women with a positive FH and metachronous bilateral breast cancer (MBBC) showed a lower local failure (HR 0.2; 95% CI 0.05-0.8). A positive FH was an independent predictor for a better disease-specific survival (HR 0.6; 95% CI 0.4-0.9). CONCLUSION: A positive FH, based on FDR implies a better prognosis in relation to survival for young women treated with BCT. In contrast to no FH for FDR, MBBC in women with a positive FH was not associated with an increased risk of local recurrence.
BACKGROUND: The aim of this study is to analyze the impact of first degree relative (FDR) of young breast cancerpatients. METHODS: Data were used from our prospective population-based cohort study which started in 1983. The family history (FH) was registered with regard to FDR: the presence or absence of invasive breast cancer in none vs. one or more FDRs at any age. RESULTS: A total of 1109 women, ≤50 years with 1128 breast conserving treatments was seen. The incidence of FDR was 17.0% for one FDR and 3.2% ≥2 FDR. The three groups, none, 1 or ≥2 FDR, were comparable. The local failure rate is comparable for all three groups. Women with a positive FH and metachronous bilateral breast cancer (MBBC) showed a lower local failure (HR 0.2; 95% CI 0.05-0.8). A positive FH was an independent predictor for a better disease-specific survival (HR 0.6; 95% CI 0.4-0.9). CONCLUSION: A positive FH, based on FDR implies a better prognosis in relation to survival for young women treated with BCT. In contrast to no FH for FDR, MBBC in women with a positive FH was not associated with an increased risk of local recurrence.
Authors: Jennifer C Melvin; Wahyu Wulaningsih; Zac Hana; Arnie D Purushotham; Sarah E Pinder; Ian Fentiman; Cheryl Gillett; Anca Mera; Lars Holmberg; Mieke Van Hemelrijck Journal: Cancer Med Date: 2016-01-22 Impact factor: 4.452